Development and Internal Validation of a Multivariable Prediction Model for Mortality After Hip Fracture with Machine Learning Techniques

• Published in: Calcified tissue international 2024-06, Vol.114 (6), p.568-582
• Main Authors: Mosfeldt, Mathias, Jørgensen, Henrik Løvendahl, Lauritzen, Jes Bruun, Jansson, Karl-Åke
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biochemistry; Biomedical and Life Sciences; Cell Biology; Denmark - epidemiology; Endocrinology; Female; Fractures; Generalized linear models; Hip; Hip Fractures - mortality; Hip Fractures - surgery; Hip joint; Humans; Learning algorithms; Life Sciences; Machine Learning; Male; Medicin och hälsovetenskap; Middle Aged; Mortality; Original Research; Orthopedics; Prediction models; Prognosis; Prospective Studies; ROC Curve
• ISSN: 1432-0827; 0171-967X; 1432-0827
• DOI: 10.1007/s00223-024-01208-1

In order to estimate the likelihood of 1, 3, 6 and 12 month mortality in patients with hip fractures, we applied a variety of machine learning methods using readily available, preoperative data. We used prospectively collected data from a single university hospital in Copenhagen, Denmark for consecutive patients with hip fractures, aged 60 years and older, treated between September 2008 to September 2010 ( n  = 1186). Preoperative biochemical and anamnestic data were used as predictors and outcome was survival at 1, 3, 6 and 12 months after the fracture. After feature selection for each timepoint a stratified split was done (70/30) before training and validating Random Forest models, extreme gradient boosting (XGB) and Generalized Linear Models. We evaluated and compared each model using receiver operator characteristic (ROC), calibration slope and intercept, Spiegelhalter’s z- test and Decision Curve Analysis. Using combinations of between 10 and 13 anamnestic and biochemical parameters we were able to successfully estimate the likelihood of mortality with an area under the curve on ROC curves of 0.79, 0.80, 0.79 and 0.81 for 1, 3, 6 and 12 month, respectively. The XGB was the overall best calibrated and most promising model. The XGB model most successfully estimated the likelihood of mortality postoperatively. An easy-to-use model could be helpful in perioperative decisions concerning level of care, focused research and information to patients. External validation is necessary before widespread use and is currently underway, an online tool has been developed for educational/experimental purposes ( https://hipfx.shinyapps.io/hipfx/ ).