Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis

ABSTRACT Apolipoprotein E (ApoE) has been associated with several diseases including Parkinson's disease, Alzheimer's and multiple sclerosis. ApoE also has documented immunomodulatory functions. We investigated gene expression in circulating monocytes and in bone marrows of patients with v...

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Bibliographic Details
Published in:Parasite immunology 2024-05, Vol.46 (5), p.e13036-n/a
Main Authors: Kausar, Gulafsha, Chauhan, Shashi B., Roy, Ritirupa, Kumar, Shashi, Engwerda, Christian, Nylen, Susanne, Kumar, Rajiv, Wilson, Mary E., Sundar, Shyam
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alzheimer's disease
ApoE
Apolipoprotein E
Apolipoproteins E - genetics
Bone Marrow
Child
Female
Gene expression
Humans
Immunomodulation
Immunoregulation
India
India - epidemiology
Inflammatory diseases
leishmaniasis
Leishmaniasis, Visceral - blood
Leishmaniasis, Visceral - immunology
Leishmaniasis, Visceral - parasitology
Lipid metabolism
Male
Middle Aged
Monocytes
Monocytes - immunology
Movement disorders
Multiple sclerosis
Neurodegenerative diseases
Parkinson's disease
Up-Regulation
Visceral leishmaniasis
Young Adult
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Summary:ABSTRACT Apolipoprotein E (ApoE) has been associated with several diseases including Parkinson's disease, Alzheimer's and multiple sclerosis. ApoE also has documented immunomodulatory functions. We investigated gene expression in circulating monocytes and in bone marrows of patients with visceral leishmaniasis (VL) living in an endemic area in Bihar, India, and contrasted these with control healthy subjects or other diagnostic bone marrows from individuals in the same region. Samples from VL patients were obtained prior to initiating treatment. Our study revealed significant upregulated expression of the apoE transcript in patients with VL. Furthermore, the levels of ApoE protein were elevated in serum samples of subjects with VL compared with healthy endemic controls. These observations may provide clues regarding the complex interactions between lipid metabolism and immunoregulation of infectious and inflammatory diseases.
ISSN:0141-9838
1365-3024
1365-3024
DOI:10.1111/pim.13036