Workshop report - interdisciplinary metabolomic epidemiology: the pathway to clinical translation

Metabolomic epidemiology studies are complex and require a broad array of domain expertise. Although many metabolite-phenotype associations have been identified; to date, few findings have been translated to the clinic. Bridging this gap requires understanding of both the underlying biology of these...

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Bibliographic Details
Published in:Metabolomics 2024-05, Vol.20 (3), p.60, Article 60
Main Authors: Zanetti, Krista A., Guo, Lining, Husain, Deeba, Kelly, Rachel S., Lasky-Su, Jessica, Broadhurst, David, Wheelock, Craig E.
Format: Article
Language:English
Subjects:
Biochemistry
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Epidemiology
Humans
Life Sciences
Medicin och hälsovetenskap
Metabolomics
Metabolomics - methods
Molecular Medicine
Ontario
Phenotypes
Translation
Translational Research, Biomedical
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Summary:Metabolomic epidemiology studies are complex and require a broad array of domain expertise. Although many metabolite-phenotype associations have been identified; to date, few findings have been translated to the clinic. Bridging this gap requires understanding of both the underlying biology of these associations and their potential clinical implications, necessitating an interdisciplinary team approach. To address this need in metabolomic epidemiology, a workshop was held at Metabolomics 2023 in Niagara Falls, Ontario, Canada that highlighted the domain expertise needed to effectively conduct these studies -- biochemistry, clinical science, epidemiology, and assay development for biomarker validation -- and emphasized the role of interdisciplinary teams to move findings towards clinical translation.
ISSN:1573-3890
1573-3882
1573-3890
DOI:10.1007/s11306-024-02111-4