Decreased spermatogonial numbers in boys with severe haematological diseases

Summary This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High‐dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 2024-07, Vol.205 (1), p.229-235
Main Authors: Lahtinen, Atte K., Funke, Miriam, Krallmann, Claudia, Wyrwoll, Margot J., Jarisch, Andrea, Yang, Yifan, Bjarnason, Ragnar, Romerius, Patrik, Sundin, Mikael, Norén‐Nyström, Ulrika, Langenskiöld, Cecilia, Cremers, Jann‐Frederik, Kliesch, Sabine, Stukenborg, Jan‐Bernd, Neuhaus, Nina, Jahnukainen, Kirsi
Format: Article
Language:English
Subjects:
Adolescent
Anemia
bone marrow failure
Chemotherapy
Child
Child, Preschool
Clinical Medicine
Fertility
Fertility Preservation - methods
Hematologi
Hematologic Diseases - therapy
Hematological diseases
Hematology
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Immunodeficiency
Infant
Klinisk medicin
Male
MDS
Medical and Health Sciences
Medicin och hälsovetenskap
Myelodysplastic syndrome
Myelodysplastic Syndromes - therapy
myeloproliferative disease
Preservation
Spermatogenesis
Spermatogenesis - radiation effects
Spermatogonia - pathology
Stem cell transplantation
Testis - pathology
Testis - radiation effects
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High‐dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/bjh.19572