Prediabetes Associates with Matrix Metalloproteinase-8 Activation and Contributes to the Rapid Destruction of Periodontal Tissues

The aim of this cross-sectional study was to investigate the relationship between periodontitis, potential periodontitis oral fluid biomarkers, and prediabetes.  This study included 150 Greek adults aged 25 to 78 years who were tested with an Hemoglobin A1C (HBA1c) diagnostic system, an active-matri...

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Bibliographic Details
Published in:European journal of dentistry 2024-10
Main Authors: Umeizudike, Kehinde Adesola, Aji, Nur Rahman Ahmad Seno, Niskanen, Katariina, Rantala, Iina, Sakellari, Dimitra, Grigoriadis, Andreas, Pätilä, Tommi, Gupta, Shipra, Sorsa, Timo, Räisänen, Ismo T
Format: Article
Language:English
Subjects:
Medicin och hälsovetenskap
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Summary:The aim of this cross-sectional study was to investigate the relationship between periodontitis, potential periodontitis oral fluid biomarkers, and prediabetes.  This study included 150 Greek adults aged 25 to 78 years who were tested with an Hemoglobin A1C (HBA1c) diagnostic system, an active-matrix metalloproteinase-8 (aMMP-8) point-of-care (PoC) test, and several salivary biomarkers enzyme-linked immunosorbent assay tests and gelatin zymography. A full-mouth clinical examination was performed to assess their periodontal and oral health status.  The Kruskal-Wallis test was used to determine the statistically significant difference in the levels of periodontal oral fluid biomarkers between the different periodontitis stages, periodontitis grades, and the stages and grades of periodontitis combined. Spearman's rank correlation was performed to assess the strength and direction of the association between aMMP-8 and HbA1c levels (
ISSN:1305-7456
1305-7464
DOI:10.1055/s-0044-1788797