Increased risk of clinically relevant neurodevelopmental disorders in survivors of congenital diaphragmatic hernia: a population-based study

• Published in: Pediatric surgery international 2024-11, Vol.40 (1), p.304, Article 304
• Main Authors: Kutasy, Balazs, Skoglund, Charlotte, Löf-Granström, Anna, Öst, Elin, Frenckner, Björn, Mesas Burgos, Carmen
• Format: Article
• Language: English
• Subjects: ADHD; ASD; Case-Control Studies; CDH; Congenital diaphragmatic hernia; Congenital diseases; Female; Hernias; Hernias, Diaphragmatic, Congenital - complications; Hernias, Diaphragmatic, Congenital - epidemiology; Humans; Incidence; Infant, Newborn; Intellectual disability; Male; Medicine; Medicine & Public Health; Neurodevelopmental disorder; Neurodevelopmental disorders; Neurodevelopmental Disorders - epidemiology; Neurodevelopmental Disorders - etiology; Original Article; Pediatric Surgery; Pediatrics; Prospective Studies; Risk Factors; Surgery; Survivors - statistics & numerical data; Sweden - epidemiology
• ISSN: 1437-9813; 0179-0358; 1437-9813
• DOI: 10.1007/s00383-024-05871-1

Purpose Neurodevelopmental disorders (ND) have been recognized as the most common and potentially most disabling outcome of congenital diaphragmatic hernia (CDH). Our aim was to evaluate the incidence of ND in patients with a history of CDH referred for ND assessment on the basis of clinically relevant symptoms rather than through a screening process. Methods The study was a nationwide, population-based prospective nested case–control study within a cohort of newborn children who survived the newborn period in Sweden during the observational period from 1st January 1982 until 31st December 2015. Results In the study period, 641 non-syndromic CDH survivors were identified, and 3080 control cases were selected. Significantly higher incidence of clinically relevant any ND (11.5% vs 5.6%, p