Sustainable Self-Aldol Condensation of Unmodified Aldehyde: A Combination of Ionic Liquid and Heterogeneous Secondary-Amine Grafted on Silica

Abstract Self-aldol condensation of an unmodified aldehyde has been effected by N-methyl-3-aminopropylated silica as a catalyst in ionic liquid, [bmim]PF 6 , to give an α,β-unsaturated aldehyde (enal). Aldehydes having acid or base sensitive substituents provided desired enals in satisfactory yields...

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Bibliographic Details
Published in:Synlett 2003-05, Vol.2003 (6)
Main Authors: Hamaya, Jun, Suzuki, Toshio, Hoshi, Takashi, Shimizu, Ken-ichi, Kitayama, Yoshie, Hagiwara, Hisahiro
Format: Article
Language:English
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Summary:Abstract Self-aldol condensation of an unmodified aldehyde has been effected by N-methyl-3-aminopropylated silica as a catalyst in ionic liquid, [bmim]PF 6 , to give an α,β-unsaturated aldehyde (enal). Aldehydes having acid or base sensitive substituents provided desired enals in satisfactory yields. The reaction system has been efficiently recycled more than eight times.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-38753