A Novel Palladium-Catalyzed Coupling of Thiol Esters with 1-Alkynes

Abstract A new method for synthesizing α,β-acetylenic ketones by palladium-mediated coupling of thiol esters with 1-alkynes is described. The reaction could be applied to coupling of thiol esters bearing various functional groups, such as aromatic bromides, and ketones, with functionalized terminal...

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Bibliographic Details
Published in:Synlett 2003-08, Vol.2003 (10)
Main Authors: Tokuyama, Hidetoshi, Miyazaki, Tohru, Yokoshima, Satoshi, Fukuyama, Tohru
Format: Article
Language:English
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Summary:Abstract A new method for synthesizing α,β-acetylenic ketones by palladium-mediated coupling of thiol esters with 1-alkynes is described. The reaction could be applied to coupling of thiol esters bearing various functional groups, such as aromatic bromides, and ketones, with functionalized terminal acetylenes.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-40861