Safe and Convenient Reduction of Δ2-Isoxazolines with PMHS-Pd(OH)2/C

Abstract A practical and safe reduction methodology for the conversion of Δ 2 -isoxazolines to 1,3-aminols is developed using polymethylhydrosiloxane-Pd(OH) 2 /C. In presence of (Boc) 2 O, the isoxazoline was converted into N-Boc protected 1,3-aminol in a one-pot procedure.

Saved in:
Bibliographic Details
Published in:Synlett 2004-06, Vol.2004 (7), p.1303-1305
Main Authors: Chandrasekhar, S., Babu, B. Nagendra, Ahmed, Moinuddin, Reddy, M. Venkat, Srihari, P., Jagadeesh, B., Prabhakar, A.
Format: Article
Language:English
Subjects:
letter
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract A practical and safe reduction methodology for the conversion of Δ 2 -isoxazolines to 1,3-aminols is developed using polymethylhydrosiloxane-Pd(OH) 2 /C. In presence of (Boc) 2 O, the isoxazoline was converted into N-Boc protected 1,3-aminol in a one-pot procedure.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2004-822917