Safe and Convenient Reduction of Δ2-Isoxazolines with PMHS-Pd(OH)2/C

Abstract A practical and safe reduction methodology for the conversion of Δ 2 -isoxazolines to 1,3-aminols is developed using polymethylhydrosiloxane-Pd(OH) 2 /C. In presence of (Boc) 2 O, the isoxazoline was converted into N-Boc protected 1,3-aminol in a one-pot procedure.

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Published in:Synlett 2004-06, Vol.2004 (7), p.1303-1305
Main Authors: Chandrasekhar, S., Babu, B. Nagendra, Ahmed, Moinuddin, Reddy, M. Venkat, Srihari, P., Jagadeesh, B., Prabhakar, A.
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container_end_page 1305
container_issue 7
container_start_page 1303
container_title Synlett
container_volume 2004
creator Chandrasekhar, S.
Babu, B. Nagendra
Ahmed, Moinuddin
Reddy, M. Venkat
Srihari, P.
Jagadeesh, B.
Prabhakar, A.
description Abstract A practical and safe reduction methodology for the conversion of Δ 2 -isoxazolines to 1,3-aminols is developed using polymethylhydrosiloxane-Pd(OH) 2 /C. In presence of (Boc) 2 O, the isoxazoline was converted into N-Boc protected 1,3-aminol in a one-pot procedure.
doi_str_mv 10.1055/s-2004-822917
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title Safe and Convenient Reduction of Δ2-Isoxazolines with PMHS-Pd(OH)2/C
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