Practical Synthesis of 2-(2-Isopropylaminothiazol-4-yl)-7-methoxy-1H-quinolin-4-one: Key Intermediate for the Synthesis of Potent HCV NS3 Protease Inhibitor BILN 2061

Abstract Herein we describe the development of an efficient, safe and practical process for the synthesis of 7-methoxy-2-(2-amino-4-thiazolyl)quinoline. Our new process allowed for a more convergent approach and eliminates the use of potentially dangerous reagents such as diazomethane used in the pr...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2006-08, Vol.2006 (15), p.2563-2567
Main Authors: Frutos, Rogelio P., Haddad, Nizar, Houpis, Ioannis N., Johnson, Michael, Smith-Keenan, Lana L., Fuchs, Victor, Yee, Nathan K., Farina, Vittorio, Faucher, Anne-Marie, Brochu, Christian, Haché, Bruno, Duceppe, Jean-Simon, Beaulieu, Pierre
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract Herein we describe the development of an efficient, safe and practical process for the synthesis of 7-methoxy-2-(2-amino-4-thiazolyl)quinoline. Our new process allowed for a more convergent approach and eliminates the use of potentially dangerous reagents such as diazomethane used in the previous discovery approach.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-2006-942472