Prognostic Significance of Ploidy and DNA Index in Patients with Epithelial Ovarian Carcinoma

• Published in: Geburtshilfe und Frauenheilkunde 2007-05, Vol.67 (5), p.475-479
• Main Authors: Projić, P., Šamija, I., Bezić, J., Tomić, S., Anđelinović, Š.
• Format: Article
• Language: English
• Subjects: Originalarbeit
• ISSN: 0016-5751; 1438-8804
• DOI: 10.1055/s-2007-965245

Abstract OBJECTIVE: To explore the significance of DNA ploidy and DNA index cutt off value to overall survival, and their potential value as independent prognostic factors. MATERIAL AND METHODS: Paraffin-embedded tissue from sixty-one ovarian epithelial cancers were analyzed by histology and flow cytometry. The results of DNA analysis were correlated with clinicopathologic data. For univariate survival analysis we used the Kaplan-Meier model and log-rank test to assess the differences between the groups. For multivariate analysis, Cox proportional hazard regression model was used to examine several parameters simultaneously. RESULTS: Aneuploidy was significantly associated with advanced clinical stage, menopausal status, high grade, serous histological type and vascular invasion. Univariate analysis showed that aneuploidy (p = 0.001) and DNA index > 1.4 (p = 0.007) were associated with shorter overall survival. Multivariate analysis showed only vascular invasion as an independent prognostic factor (p < 0.001). CONCLUSIONS: Although abnormal DNA content was associated with traditional clinicopathological characteristics for aggressive tumors and shorter overall survival, aneuploidy and high DNA index had no independent prognostic value in our study.