Why Is Living Fast Dangerous? Disentangling the Roles of Resistance and Tolerance of Disease

Primary axes of host developmental tempo (HDT; e.g., slow-quick return continuum) represent latent biological processes and are increasingly used to a priori identify hosts that contribute disproportionately more to pathogen transmission. The influence of HDT on host contributions to transmission de...

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Bibliographic Details
Published in:The American naturalist 2014-08, Vol.184 (2), p.172-187
Main Authors: Cronin, James P., Rúa, Megan A., Mitchell, Charles E.
Format: Article
Language:English
Subjects:
Animals
Average linear density
Biomass
Coefficients
Disease transmission
Disease Vectors
Grasses
Infections
Models, Theoretical
Nonnative species
Parasite hosts
Pathogens
Phenotype
Phenotypes
Phylogenetics
Phylogeny
Plant Diseases - virology
Plant Viruses - physiology
Poaceae - growth & development
Poaceae - virology
Soil resources
Viruses
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Summary:Primary axes of host developmental tempo (HDT; e.g., slow-quick return continuum) represent latent biological processes and are increasingly used to a priori identify hosts that contribute disproportionately more to pathogen transmission. The influence of HDT on host contributions to transmission depends on how HDT influences both resistance and tolerance of disease. Here, we use structural equation modeling to address known limitations of conventional measures of resistance and tolerance. We first provide a general resistance-tolerance metamodel from which system-specific models can be derived. We then develop a model specific to a group of vector-transmitted viruses that infect hundreds of grass species worldwide. We tested the model using experimental inoculations of six phylogenetically paired grass species. We found that (1) host traits covaried according to a prominent HDT axis, the slow-quick continuum; (2) infection caused a greater reduction in the performance of quick returns, with >80% of that greater impact explained by lesser resistance; (3) resistance-tolerance trade-off did not occur; and (4) phylogenetic control was necessary to measure the slow-quick continuum, resistance, and tolerance. These results support the conclusion that HDT’s main influence on host contributions to transmission is via resistance. More broadly, this study provides a framework for quantifying HDT’s influence on host contributions to transmission.
ISSN:0003-0147
1537-5323
DOI:10.1086/676854