The Levels of Sera Malondialdehyde, Erythrocyte Membrane Na+-K+/Mg++ and Ca++/Mg++ Adenosine 5' Triphosphatase in Patients with Sickle Cell Anemia

The various membrane abnormalities of sickle erythrocytes may result from excessive accumulation of oxidant damage. We measured the sera levels of malondialdehyde, products of lipid peroxidation, Na+-K+/Mg++ Adenosine 5' triphosphatase (ATPase) and Ca++/Mg++ Adenosine 5' triphosphatase, er...

Full description

Saved in:
Bibliographic Details
Published in:Turkish journal of haematology 2000-03, Vol.17 (1), p.23-26
Main Authors: Tamer, L, Polat, G, Yücebilgiç, G, Güvenç, B, Başlamışlı, F
Format: Article
Language:English
Subjects:
Adenosinetriphosphatase
Adenozintrifosfataz
Anemi, orak hücreli
Anemia, Sickle Cell
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Doğumsal, kalıtsal ve yenidoğan hastalıkları ve anomaliler
Eritrosit membranı
Erythrocyte Membrane
Hematologic Diseases
Hematolojik hastalıklar
Hemic and lymphatic diseases
Hemik ve lenfatik hastalıklar
Malondialdehit
Malondialdehyde
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The various membrane abnormalities of sickle erythrocytes may result from excessive accumulation of oxidant damage. We measured the sera levels of malondialdehyde, products of lipid peroxidation, Na+-K+/Mg++ Adenosine 5' triphosphatase (ATPase) and Ca++/Mg++ Adenosine 5' triphosphatase, erythrocyte membrane enzymes, in patients with sickle cell anemia and compared their levels with that of normal controls. MDA, Na+-K+/Mg++ and Ca++/Mg++ ATPase levels of control groups were 0.90 ± 0.04 nmol/mL, 168 ± 12.9 and 140.6 ± 8.2 nmol Pi/mg prot/hour, respectively. MDA, Na+-K+/Mg++ and Ca++/Mg++ATPase levels of patients were 2.02 ± 0.01 nmol/mL, 127.0 ± 8.4 and 110.0 ± 9.6 nmol Pi/mg prot/hour, respectively. Our experimental results showed that there was a significant increase in MDA levels of patients with sickle cell anemia as compared with that of the controls. However, erythrocyte membrane Na+-K+/Mg++ and Ca++/Mg++ ATPase levels of patients with sickle cell anemia were significantly lower than the, Na+-K+/Mg++ and Ca++/Mg++ ATPase levels of normal controls.
ISSN:1300-7777