Preclinical test for prion diseases

Here we suggest a possible approach to an early preclinical diagnostic method for transmissible spongiform encephalopathies using scrapie in sheep as a model. An altered protein, PrP super(Sc), can be detected in the brain of diseased individuals. We have now detected PrP super(Sc) in tonsils of she...

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Bibliographic Details
Published in:Nature (London) 1996-06, Vol.381 (6583), p.563-563
Main Authors: Schreuder, B. E. C, van Keulen, L. J. M, Vromans, M. E. W, Langeveld, J. P. M, Smits, M. A
Format: Article
Language:English
Subjects:
Alleles
Animals
Bioassays
Biopsy
Cattle
Creutzfeldt-Jakob disease
Humanities and Social Sciences
Humans
ID Lelystad, Institute for Animal Science and Health
ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid
multidisciplinary
Palatine Tonsil - metabolism
Prion Diseases - diagnosis
Proteins
PrPSc Proteins - analysis
PrPSc Proteins - genetics
Science
Science (multidisciplinary)
scientific-correspondence
Scrapie - diagnosis
Sheep
Time Factors
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Summary:Here we suggest a possible approach to an early preclinical diagnostic method for transmissible spongiform encephalopathies using scrapie in sheep as a model. An altered protein, PrP super(Sc), can be detected in the brain of diseased individuals. We have now detected PrP super(Sc) in tonsils of sheep in the preclinical stage of the disease, long before the onset of clinical signs.
ISSN:0028-0836
1476-4687
DOI:10.1038/381563a0