Workshop studies with monoclonal antibodies identifying a novel porcine differentiation antigen, SWC9

Two monoclonal antibodies (mAb) within cluster M4 of the myeloid section of the Second International Swine CD Workshop, C4 (No. 144) and PM18-7 (No. 192), showed reactivity with thymocytes and among cells of myelomonocytic origin with mature macrophages but not with monocytes and granulocytes. Both...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 1998-01, Vol.60 (3), p.343-349
Main Authors: Dominguez, J, Ezquerra, A, Alonso, F, Bullido, R, McCullough, K, Summerfield, A, Bianchi, A, Zwart, R.J, Kim, Y.B, Blecha, F, Eicher, S, Murtaugh, M.P, Pampusch, M, Burger, K
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - metabolism
ANTICORPS MONOCLONAL
ANTICUERPOS MONOCLONALES
ANTIGEN ANTIBODY REACTIONS
ANTIGENE
ANTIGENOS
ANTIGENS
Antigens, Differentiation, Myelomonocytic - analysis
CERDO
Differentiation antigen
ID Lelystad, Institute for Animal Science and Health
ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid
Kinetics
MACROFAGOS
MACROPHAGE
MACROPHAGES
Macrophages - immunology
Macrophages, Alveolar - immunology
MONOCLONAL ANTIBODIES
Monoclonal antibody
Monocytes - immunology
PORCIN
Precipitin Tests
REACCION ANTIGENO ANTICUERPO
REACTION ANTIGENE ANTICORPS
SWINE
Swine - immunology
Swine, Miniature
T-Lymphocyte Subsets - immunology
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Description
Summary:Two monoclonal antibodies (mAb) within cluster M4 of the myeloid section of the Second International Swine CD Workshop, C4 (No. 144) and PM18-7 (No. 192), showed reactivity with thymocytes and among cells of myelomonocytic origin with mature macrophages but not with monocytes and granulocytes. Both mAb recognize a protein showing two bands of 205 kDa and 130 kDa under both reducing and non-reducing conditions. Although epitope mapping with these mAb could not be performed, this cluster received the SWC9 designation.
ISSN:0165-2427
1873-2534
DOI:10.1016/S0165-2427(97)00110-4