Comparative map between chicken chromosome 15 and human chromosomal region 12q24 and 22q11-q12

The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS deri...

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Bibliographic Details
Published in:Mammalian genome 2003-09, Vol.14 (9), p.629-639
Main Authors: Jennen, Danyel G J, Crooijmans, Richard P M A, Kamps, Bram, Açar, Rukiye, van der Poel, Jan J, Groenen, Martien A M
Format: Article
Language:English
Subjects:
Animals
Base Sequence
beta-Crystallins - genetics
Chickens - genetics
chromosome 12
chromosome 15
chromosome 22
Chromosome Mapping
Chromosomes, Artificial, Bacterial - genetics
Chromosomes, Human, Pair 12 - genetics
Chromosomes, Human, Pair 22 - genetics
Contig Mapping
DNA - genetics
evolution
Gene Rearrangement
genes
Genetic Markers
genome rearrangements
human-chromosome-22
Humans
linkage map
Mice
Molecular Sequence Data
mouse chromosome-5
Multigene Family
sequence-tagged sites
Species Specificity
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Summary:The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.
ISSN:0938-8990
1432-1777
DOI:10.1007/s00335-003-3007-z