Divergent antibody responses to vaccines and divergent body weights of chicken lines selected for high and low humoral responsiveness to sheep red blood cells

Primary and secondary antibody responses to intramuscularly administered proteins of Escherichia coli (F11), Newcastle disease virus (NCD), infectious bronchitis virus (IB), and infectious bursar disease virus (IBD), respectively, were measured at weekly intervals in two chicken lines. The latter ha...

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Bibliographic Details
Published in:Avian diseases 1996-07, Vol.40 (3), p.634-644
Main Authors: Parmentier, H.K. (Agricultural University, Wageningen, The Netherlands.), Nieuwland, M.G.B, Rijke, E, Reilingh, G. de V, Schrama, J.W
Format: Article
Language:English
Subjects:
Animal Husbandry
Animals
Antibodies
Antibodies, Bacterial - blood
Antibodies, Viral - blood
Antibody Formation
Antigens
Bacterial Vaccines - immunology
Body Weight
Cell lines
Chickens
Chickens - immunology
DIFERENCIAS BIOLOGICAS
DIFFERENCE BIOLOGIQUE
ERITROCITOS
ERYTHROCYTE
Erythrocytes
Erythrocytes - immunology
ESCHERICHIA COLI
Escherichia coli - immunology
Female
GENETICA
GENETIQUE
H lines
IMMUNITE HUMORALE
Infectious bronchitis virus - immunology
Infectious bursal disease virus - immunology
INMUNIDAD HUMORAL
Male
Newcastle disease virus - immunology
OVIN
OVINOS
PESO
POIDS
POLLO
POULET
REPONSE IMMUNITAIRE
RESISTANCE AUX MALADIES
RESISTENCIA A LA ENFERMEDAD
RESPUESTA INMUNOLOGICA
SELECCION
SELECTION
Sensitization
Sheep - blood
VACCIN
Vaccination
Vaccines - immunology
VACUNA
Veehouderij
Viral Vaccines - immunology
VIRUS BRONCHITE INFECTIEUSE AVIAIRE
VIRUS BRONQUITIS INFECCIOSA AVIAR
VIRUS BURSITE INFECTIEUSE
VIRUS BURSITIS INFECCIOSA
VIRUS DE LA ENFERMEDAD DE NEWCASTLE
VIRUS MALADIE DE NEWCASTLE
WIAS
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Summary:Primary and secondary antibody responses to intramuscularly administered proteins of Escherichia coli (F11), Newcastle disease virus (NCD), infectious bronchitis virus (IB), and infectious bursar disease virus (IBD), respectively, were measured at weekly intervals in two chicken lines. The latter had been divergency selected for high and low antibody responses to sheep red blood cells (SRBC), and in a random-bred control line. An oil-based adjuvant was required to induce primary and secondary antibody responses to NCD, IB, and IBD. With respect to F11, elevated antibody responses were found in birds sensitized and boosted to F11 with and without adjuvant. The humoral response to F11 and to all viral antigens was significantly higher in the high (H) line than in the low (L) line, whereas the control (C) line showed intermediate titers. At 5 and 17 weeks of age, L line birds were significantly heavier than birds of the H and the C lines. A negative phenotypic correlation within lines between body weight at 17 weeks of age and antibody titers at 1 week after sensitization was found, but no further correlations between humoral responses and body weight or growth could be established. The present results suggest that selection for enhanced humoral responsiveness to SRBC resulted in enhanced responsiveness to components of several vaccines. Mechanisms underlying the relationship between divergent selection for immune responsiveness and body weight are discussed
ISSN:0005-2086
1938-4351
DOI:10.2307/1592275