Candida Rugosa Lipase-catalyzed Kinetic Resolution of 3-(Isobutyryloxy)methyl 4-[2-(Difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate

The lipase-catalyzed kinetic resolution of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate has been performed. The most enantioselective reaction (E = 28) was transesterification with n-butanol in water-saturated toluene at...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2004-07, Vol.40 (7), p.931-937
Main Authors: Sobolev, A., Zhalubovskis, R., Franssen, M. C. R., Vigante, B., Chekavichus, B., Duburs, G., de Groot, Ae
Format: Article
Language:English
Subjects:
Laboratorium voor Organische chemie
Laboratory for Organic Chemistry
Organic Chemistry
Organische Chemie
VLAG
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Summary:The lipase-catalyzed kinetic resolution of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate has been performed. The most enantioselective reaction (E = 28) was transesterification with n-butanol in water-saturated toluene at 45°C
ISSN:0009-3122
1573-8353
DOI:10.1023/B:COHC.0000044578.17992.95