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Myricetin stimulates the absorption of the pro-carcinogen PhIP
The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to...
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| Published in: | Cancer letters 2006-01, Vol.231 (1), p.36-42 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c439t-bf26eeb9306b45d3762f793759165f723be005e8e57259bf88f2ebc84b63341e3 |
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| cites | cdi_FETCH-LOGICAL-c439t-bf26eeb9306b45d3762f793759165f723be005e8e57259bf88f2ebc84b63341e3 |
| container_end_page | 42 |
| container_issue | 1 |
| container_start_page | 36 |
| container_title | Cancer letters |
| container_volume | 231 |
| creator | Schutte, Maaike E. van de Sandt, Johannes J.M. Alink, Gerrit M. Groten, John P. Rietjens, Ivonne M.C.M. |
| description | The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-
b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport.
The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen. |
| doi_str_mv | 10.1016/j.canlet.2005.01.020 |
| format | article |
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b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport.
The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2005.01.020</identifier><identifier>PMID: 16356829</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>ABC transporter ; ABC transporters ; Absorption ; apparent drug permeability ; Apparent permeability ; ATP-Binding Cassette Transporters - physiology ; Caco-2 ; Caco-2 Cells ; Carcinogens - pharmacokinetics ; Cell culture ; cells ; Experiments ; expression ; Flavonoids - pharmacology ; Humans ; Imidazoles - pharmacokinetics ; localization ; Membrane Transport Proteins - metabolism ; modulation ; Multidrug Resistance-Associated Proteins - antagonists & inhibitors ; Multidrug Resistance-Associated Proteins - metabolism ; multidrug-resistance protein-1 ; mutagen ; Myricetin ; Permeability ; PhIP ; potentially anticarcinogenic flavonoids ; Proteins ; Studies ; transport</subject><ispartof>Cancer letters, 2006-01, Vol.231 (1), p.36-42</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited Jan 8, 2006</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-bf26eeb9306b45d3762f793759165f723be005e8e57259bf88f2ebc84b63341e3</citedby><cites>FETCH-LOGICAL-c439t-bf26eeb9306b45d3762f793759165f723be005e8e57259bf88f2ebc84b63341e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16356829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schutte, Maaike E.</creatorcontrib><creatorcontrib>van de Sandt, Johannes J.M.</creatorcontrib><creatorcontrib>Alink, Gerrit M.</creatorcontrib><creatorcontrib>Groten, John P.</creatorcontrib><creatorcontrib>Rietjens, Ivonne M.C.M.</creatorcontrib><title>Myricetin stimulates the absorption of the pro-carcinogen PhIP</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-
b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport.
The results indicate that myricetin induces an increased basolateral uptake of the pro-carcinogen PhIP, in part through inhibition of the MRP2 mediated excretion of PhIP from the intestinal cells back to the lumen.</description><subject>ABC transporter</subject><subject>ABC transporters</subject><subject>Absorption</subject><subject>apparent drug permeability</subject><subject>Apparent permeability</subject><subject>ATP-Binding Cassette Transporters - physiology</subject><subject>Caco-2</subject><subject>Caco-2 Cells</subject><subject>Carcinogens - pharmacokinetics</subject><subject>Cell culture</subject><subject>cells</subject><subject>Experiments</subject><subject>expression</subject><subject>Flavonoids - pharmacology</subject><subject>Humans</subject><subject>Imidazoles - pharmacokinetics</subject><subject>localization</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>modulation</subject><subject>Multidrug Resistance-Associated Proteins - antagonists & inhibitors</subject><subject>Multidrug Resistance-Associated Proteins - metabolism</subject><subject>multidrug-resistance protein-1</subject><subject>mutagen</subject><subject>Myricetin</subject><subject>Permeability</subject><subject>PhIP</subject><subject>potentially anticarcinogenic flavonoids</subject><subject>Proteins</subject><subject>Studies</subject><subject>transport</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kEuLFDEUhYMoTjv6D0QKXFeZZyXlYkAGHwMjzkLXl0r6lpOmOmmTlMP8e1NWgzs3uRDOOffcj5DXjHaMsv7doXNjmLF0nFLVUdZRTp-QHTOat3ow9CnZUUFlK4xQF-RFzgdahVKr5-SC9UL1hg87cvX1MXmHxYcmF39c5rFgbso9NqPNMZ2Kj6GJ09-fU4qtG5PzIf7E0Nzd39y9JM-mcc746jwvyY9PH79ff2lvv32-uf5w2zophtLaifeIdhC0t1Lthe75pAeh1cB6NWkuLNZuaFBprgY7GTNxtM5I2wshGYpL8n7LfRjrah_qA2GtkiGOHmZv05ge4WFJEOZ1nBabQUjO5VDNbzdzPeDXgrnAIS4p1L7AFFVCc2lMVclN5VLMOeEEp-SPayqjsBKHA2zEYSUOlEElXm1vzuGLPeL-n-mMuAquNgFWPr89JsjOY3C49wldgX30_9_wBwgek-0</recordid><startdate>20060108</startdate><enddate>20060108</enddate><creator>Schutte, Maaike E.</creator><creator>van de Sandt, Johannes J.M.</creator><creator>Alink, Gerrit M.</creator><creator>Groten, John P.</creator><creator>Rietjens, Ivonne M.C.M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>QVL</scope></search><sort><creationdate>20060108</creationdate><title>Myricetin stimulates the absorption of the pro-carcinogen PhIP</title><author>Schutte, Maaike E. ; van de Sandt, Johannes J.M. ; Alink, Gerrit M. ; Groten, John P. ; Rietjens, Ivonne M.C.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-bf26eeb9306b45d3762f793759165f723be005e8e57259bf88f2ebc84b63341e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ABC transporter</topic><topic>ABC transporters</topic><topic>Absorption</topic><topic>apparent drug permeability</topic><topic>Apparent permeability</topic><topic>ATP-Binding Cassette Transporters - physiology</topic><topic>Caco-2</topic><topic>Caco-2 Cells</topic><topic>Carcinogens - pharmacokinetics</topic><topic>Cell culture</topic><topic>cells</topic><topic>Experiments</topic><topic>expression</topic><topic>Flavonoids - pharmacology</topic><topic>Humans</topic><topic>Imidazoles - pharmacokinetics</topic><topic>localization</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>modulation</topic><topic>Multidrug Resistance-Associated Proteins - antagonists & inhibitors</topic><topic>Multidrug Resistance-Associated Proteins - metabolism</topic><topic>multidrug-resistance protein-1</topic><topic>mutagen</topic><topic>Myricetin</topic><topic>Permeability</topic><topic>PhIP</topic><topic>potentially anticarcinogenic flavonoids</topic><topic>Proteins</topic><topic>Studies</topic><topic>transport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schutte, Maaike E.</creatorcontrib><creatorcontrib>van de Sandt, Johannes J.M.</creatorcontrib><creatorcontrib>Alink, Gerrit M.</creatorcontrib><creatorcontrib>Groten, John P.</creatorcontrib><creatorcontrib>Rietjens, Ivonne M.C.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>NARCIS:Publications</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schutte, Maaike E.</au><au>van de Sandt, Johannes J.M.</au><au>Alink, Gerrit M.</au><au>Groten, John P.</au><au>Rietjens, Ivonne M.C.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myricetin stimulates the absorption of the pro-carcinogen PhIP</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2006-01-08</date><risdate>2006</risdate><volume>231</volume><issue>1</issue><spage>36</spage><epage>42</epage><pages>36-42</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-
b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to the basolateral compartment. This effect was observed at physiologically relevant concentrations of PhIP and myricetin. Cyclosporin A (MRP2 inhibitor) but not PSC833 (P-gp inhibitor) showed a similar effect on PhIP transport.
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| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2006-01, Vol.231 (1), p.36-42 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_wageningen_narcis_oai_library_wur_nl_wurpubs_342249 |
| source | ScienceDirect Freedom Collection |
| subjects | ABC transporter ABC transporters Absorption apparent drug permeability Apparent permeability ATP-Binding Cassette Transporters - physiology Caco-2 Caco-2 Cells Carcinogens - pharmacokinetics Cell culture cells Experiments expression Flavonoids - pharmacology Humans Imidazoles - pharmacokinetics localization Membrane Transport Proteins - metabolism modulation Multidrug Resistance-Associated Proteins - antagonists & inhibitors Multidrug Resistance-Associated Proteins - metabolism multidrug-resistance protein-1 mutagen Myricetin Permeability PhIP potentially anticarcinogenic flavonoids Proteins Studies transport |
| title | Myricetin stimulates the absorption of the pro-carcinogen PhIP |
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