Effects of acute and repeated administration of a cholinesterase inhibitor on timing behaviour

It has been hypothesised that a leftward shift in the response distribution obtained in the peak interval (PI) procedure is a characteristic of cognitive enhancement in which mental processes are speeded. Metrifonate, a cholinesterase inhibitor with reported cognitive enhancing properties in many an...

Full description

Saved in:
Bibliographic Details
Published in:European neuropsychopharmacology 2004-08, Vol.14 (4), p.285-294
Main Authors: Bouger, Pascale C, Spowart-Manning, Laura, Ferrara, Andre, Schmidt, Bernard H, van der Staay, Franz-Josef
Format: Article
Language:English
Subjects:
aged rats
aging rabbits
alzheimers-disease
Animals
Behavior, Animal - drug effects
brain acetylcholine
Cholinesterase inhibitor
Cholinesterase Inhibitors - pharmacology
Discrimination (Psychology) - drug effects
Dose-Response Relationship, Drug
Drug Administration Schedule
Human health sciences
internal clock
Male
Mental Processes - drug effects
Metrifonate
Models, Psychological
Neurologie
Neurology
Neurosciences & behavior
Neurosciences & comportement
Peak interval procedure
preclinical pharmacology
Rats
Scalar expectancy theory
Sciences de la santé humaine
Sciences sociales & comportementales, psychologie
Social & behavioral sciences, psychology
temporal memory
time perception
Time Perception - drug effects
Timing behaviour
transformation product dichlorvos
Trichlorfon - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has been hypothesised that a leftward shift in the response distribution obtained in the peak interval (PI) procedure is a characteristic of cognitive enhancement in which mental processes are speeded. Metrifonate, a cholinesterase inhibitor with reported cognitive enhancing properties in many animal models of learning and memory, was tested in the PI procedure. Acute administration of 3 and 60 mg/kg but not 1 and 30 mg/kg in fully trained rats shifted the response distribution to the right, whereas subchronic administration of 10, 30 or 50 mg/kg during task acquisition had no effect on timing behaviour. On the basis of the present data, it can be concluded that the effects of a cognition enhancer in the PI procedure cannot be predicted from the scalar expectancy theory (SET). Furthermore, SET does not appear to be an appropriate tool for analysing the acquisition of timing behaviour.
ISSN:0924-977X
1873-7862
1873-7862
DOI:10.1016/j.euroneuro.2003.08.011