Effect of vitamin a supplementation for 3 days on iron metabolism, liver function indicator enzymes and differential cell counts in bone marrow of rats with severe vitamin a deficiency

Rats with severe vitamin A deficiency were supplemented with vitamin A for 3 days; control rats were not supplemented. Vitamin A supplementation produced an increase in plasma retinol levels, but iron metabolism as assessed by hematological variables, plasma iron concentration, total iron-binding ca...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 1996-11, Vol.16 (11), p.1933-1941
Main Authors: Roodenburg, Annet J.C., Van Pelt, Ans M.M., West, Clive E., Beynen, Anton C.
Format: Article
Language:English
Subjects:
Afdeling Humane voeding
ALANINA AMINOTRANSFERASA
ALANINE AMINOTRANSFERASE
ASPARTATE AMINOTRANSFERASE
ASPARTATO AMINOTRANSFERASA
BAZO
Biological and medical sciences
bone marrow cells
CARENCE EN VITAMINE
CELLULE
CELULAS
COMPLEMENT ALIMENTAIRE
DEFICIENCIA DE VITAMINAS
DIAGNOSTIC
DIAGNOSTICO
FER
FOIE
FONCTION PHYSIOLOGIQUE
FOSFATASA ALCALINA
FUNCION FISIOLOGICA
General and cellular metabolism. Vitamins
HEMATOPOIESE
HEMATOPOIESIS
HIERRO
HIGADO
HUESOS DE LOS MIEMBROS
Human Nutrition
Human Nutrition & Health
Human Nutrition (HNE)
Humane Voeding
Humane Voeding & Gezondheid
iron status
liver enzymes
Medical sciences
MEDULA OSEA
METABOLISME DES MINERAUX
METABOLISMO DE MINERALES
MOELLE OSSEUSE
OS DES MEMBRES
PESO
Pharmacology. Drug treatments
PHOSPHATASE ALCALINE
PLASMA SANGUIN
PLASMA SANGUINEO
POIDS
RAT
RATA
RATE
REIN
RETINOL
RINONES
SANG
SANGRE
SUPLEMENTOS
vitamin A deficiency
vitamin A supplementation
VITAMINAS
VITAMINE
VLAG
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Summary:Rats with severe vitamin A deficiency were supplemented with vitamin A for 3 days; control rats were not supplemented. Vitamin A supplementation produced an increase in plasma retinol levels, but iron metabolism as assessed by hematological variables, plasma iron concentration, total iron-binding capacity and organ iron content was not affected. The high plasma concentrations of alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) in the control rats, indicative of liver damage, were normalized by vitamin A supplementation. Differential counts of bone marrow cells revealed that vitamin A supplementation increased myelopoiesis relative to erythropoiesis. We conclude that vitamin A supplementation for 3 days to rats with severe vitamin A deficiency corrects liver damage, influences blood cell synthesis, but does not affect iron status.
ISSN:0271-5317
1879-0739
DOI:10.1016/S0271-5317(96)00216-3