Cell culture from sponges: pluripotency and immortality

Sponges are a source of compounds with potential pharmaceutical applications. In this article, methods of sponge cell culture for production of these bioactive compounds are reviewed, and new approaches for overcoming the problem of metabolite supply are examined. The use of embryos is proposed as a...

Full description

Saved in:
Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2007-10, Vol.25 (10), p.467-471
Main Authors: de Caralt, Sònia, Uriz, María J, Wijffels, René H
Format: Article
Language:English
Subjects:
Animal cells
Animals
Apoptosis
Apoptosis - physiology
Bacteria
Bioactive compounds
Biological and medical sciences
Biotechnology
Cell culture
Cell Culture Techniques - methods
Cell Culture Techniques - trends
Cell Differentiation
Cell division
Cell Line - cytology
Cell Line - physiology
Cell Proliferation
Cell Survival
Chemical elements
demospongiae
Embryos
Eukaryotic cell cultures
Fundamental and applied biological sciences. Psychology
Genetic engineering
growth dynamics
hymeniacidon-perleve
in-vitro
Internal Medicine
Mammals
marine
Metabolites
Methods. Procedures. Technologies
Microorganisms
Miscellaneous
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - physiology
porifera
Porifera - cytology
Porifera - physiology
Stem cells
stem-cell
strategies
Studies
suberites-domuncula
Success
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sponges are a source of compounds with potential pharmaceutical applications. In this article, methods of sponge cell culture for production of these bioactive compounds are reviewed, and new approaches for overcoming the problem of metabolite supply are examined. The use of embryos is proposed as a new source of sponge material for cell culture. Stem cells are present in high amounts in embryos and are more versatile and resistant to infections than adult cells. Additionally, genetic engineering and cellular research on apoptotic mechanisms are promising new fields that might help to improve cell survival in sponge-cell lines. We propose that one topic for future research should be how to reduce apoptosis, which appears to be very high in sponge cell cultures.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2007.08.006