A new type of steroids with a cyclobutane fragment in the AB-ring moiety

The synthesis of a 5,10-seco steroid containing two double bonds in a AB-macrocycle as well as the preparation of a steroidal skeleton with a cyclobutane fragment is described. The structures of these compounds are different from those of natural steroids, but they are very similar with respect to c...

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Bibliographic Details
Published in:Steroids 2006-06, Vol.71 (6), p.445-449
Main Authors: Khripach, Vladimir A., Zhabinskii, Vladimir N., Fando, Galina P., Kuchto, Anna I., Khripach, Natalya B., Groen, Marinus B., van der Louw, Jaap, de Groot, Aede
Format: Article
Language:English
Subjects:
[2+2]Photocycloaddition
Cyclobutane steroids
Cyclobutanes - chemistry
Cyclodeca-1,6-dienes
derivatives
inhibitors
Models, Molecular
Molecular Conformation
Molecular Structure
Oxidation-Reduction
Ozone - chemistry
Ozonolysis
Reduction
Seco steroids
Secosteroids - chemical synthesis
Secosteroids - chemistry
Steroids - chemistry
Structure-Activity Relationship
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Summary:The synthesis of a 5,10-seco steroid containing two double bonds in a AB-macrocycle as well as the preparation of a steroidal skeleton with a cyclobutane fragment is described. The structures of these compounds are different from those of natural steroids, but they are very similar with respect to conformation of the carbon skeleton.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2006.01.010