Theory of polyelectrolyte adsorption on heterogeneously charged surfaces applied to soluble protein–polyelectrolyte complexes

Existing theoretical approaches to polymer adsorption on heterogeneous surfaces are applied to the problems of polyelectrolyte and polyampholyte adsorption on randomly charged surfaces. Also, analytical estimates are developed for the critical pH at which weakly charged polyelectrolytes and globular...

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Bibliographic Details
Published in:The Journal of chemical physics 2003-03, Vol.118 (10), p.4649-4659
Main Authors: de Vries, R., Weinbreck, F., de Kruif, C. G.
Format: Article
Language:English
Subjects:
bovine beta-lactoglobulin
density
interfaces
monte-carlo
polyampholyte chain
polymer adsorption
transition
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Summary:Existing theoretical approaches to polymer adsorption on heterogeneous surfaces are applied to the problems of polyelectrolyte and polyampholyte adsorption on randomly charged surfaces. Also, analytical estimates are developed for the critical pH at which weakly charged polyelectrolytes and globular proteins start forming soluble complexes. Below a critical salt concentration, soluble complexes form “on the wrong side” of the protein isoelectric point due to the heterogeneity of the protein surface charge distribution. The analytical estimates are consistent with experimental data on soluble complexes in mixtures of gum arabic and whey protein isolate.
ISSN:0021-9606
1089-7690
DOI:10.1063/1.1543981