DEET microencapsulation: a slow-release formulation enhancing the residual efficacy of bed nets against malaria vectors

Textile materials treated with synthetic repellents have the potential to provide protection against insect disease vectors but lack the residual activity necessary to achieve a prolonged effect or to be cost-effective. DEET MC is a formulation of DEET (N,N diethyl-m-toluamide) in which the repellen...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2008-03, Vol.102 (3), p.259-262
Main Authors: N’Guessan, Raphael, Knols, Bart G.J., Pennetier, Cedric, Rowland, Mark
Format: Article
Language:English
Subjects:
Animal biology
Animals
Anopheles
Bed nets
Bedding and Linens - utilization
Biological and medical sciences
Culex
culicidae
DEET
DEET - administration & dosage
diptera
Drug Compounding
Efficacy
Galenic pharmacology
Human protozoal diseases
Humans
Infectious diseases
Insect Bites and Stings - parasitology
Insect Repellents - administration & dosage
insecticide
Insecticide Resistance
Invertebrate Zoology
Life Sciences
Malaria
Malaria - prevention & control
Medical sciences
Microencapsulation
Mosquito Control - methods
mosquito nets
Parasitic diseases
Pharmaceutical sciences
Prevention
Protozoal diseases
Pyrethrins
pyrethroid resistance
resistant anopheles-gambiae
Statistics as Topic
synthetic repellents
Time Factors
treated nets
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Summary:Textile materials treated with synthetic repellents have the potential to provide protection against insect disease vectors but lack the residual activity necessary to achieve a prolonged effect or to be cost-effective. DEET MC is a formulation of DEET (N,N diethyl-m-toluamide) in which the repellent is gradually released from a capsule that binds the repellent. An experiment carried out on DEET-treated mosquito netting showed that the formulation repels, inhibits blood-feeding and kills mosquitoes for a period of at least 6 months under laboratory conditions. Such formulations may have the potential for use on nets against pyrethroid-resistant mosquitoes or on clothing or bedding materials distributed in disasters, emergencies or refugee camp situations.
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2007.10.012