Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate 1-3

Background: Random serial sampling is widely used in population pharmacokinetic studies and may have advantages compared with conventional fixed time-point evaluation of iron fortification. Objective: Our objective was to validate random serial sampling to judge the efficacy of iron fortification of...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2010, Vol.92 (5)
Main Authors: Andersson, M, Theis, W, Zimmermann, M.B, Forman, J.T, Jakel, M, Duchateau, G.S.M.J.E, Frenken, L.G.J, Hurrell, R.F
Format: Article
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Subjects:
absorption
deficiency
double-blind
dual fortification
iodine
population pharmacokinetics
relative bioavailability
salt
transferrin receptor
whole diet
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Summary:Background: Random serial sampling is widely used in population pharmacokinetic studies and may have advantages compared with conventional fixed time-point evaluation of iron fortification. Objective: Our objective was to validate random serial sampling to judge the efficacy of iron fortification of a low-fat margarine. Design: We conducted a 32-wk placebo-controlled, double-blind, iron-intervention trial in 18–40-y-old Swiss women (n = 142) with serum ferritin (SF) concentrations
ISSN:0002-9165
1938-3207