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The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network
Dietary Zn recommendations vary widely across Europe due to the heterogeneity of approaches used by expert panels. Under the EURopean micronutrient RECommendations Aligned (EURRECA) consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a d...
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Published in: | British journal of nutrition 2012-12, Vol.108 (11), p.1962-1971 |
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container_end_page | 1971 |
container_issue | 11 |
container_start_page | 1962 |
container_title | British journal of nutrition |
container_volume | 108 |
creator | Lowe, Nicola M. Medina, Marisol Warthon Stammers, Anna-Louise Patel, Sujata Souverein, Olga W. Dullemeijer, Carla Serra-Majem, Lluis Nissensohn, Mariela Hall Moran, Victoria |
description | Dietary Zn recommendations vary widely across Europe due to the heterogeneity of approaches used by expert panels. Under the EURopean micronutrient RECommendations Aligned (EURRECA) consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a database that includes ‘best practice’ guidelines which can be used as a resource by future panels when setting micronutrient recommendations. As part of this process, the objective of the present study was to undertake a systematic review and meta-analysis of previously published data describing the relationship between Zn intake and status in adults. Searches were performed of literature published up to February 2010 using MEDLINE, Embase and the Cochrane Library. Data extracted included population characteristics, dose of Zn, duration of study, dietary intake of Zn, and mean concentration of Zn in plasma or serum at the end of the intervention period. An intake–status regression coefficient ($\circ {>\beta }$) was estimated for each individual study, and pooled meta-analysis undertaken. The overall pooled $\circ {>\beta }$ for Zn supplementation on serum/plasma Zn concentrations from randomised controlled trials and observational studies was 0·08 (95 % CI 0·05, 0·11; P \beta }$ of 0·08 means that for every doubling in Zn intake, the difference in Zn serum or plasma concentration is $2^{ \circ {>\beta }}$ (20·08 = 1·06), which is 6 %. Whether the dose–response relationship, as provided in the present paper, could be used as either qualitative or quantitative evidence to substantiate the daily Zn intake dose necessary to achieve normal or optimal levels of biomarkers for Zn status remains a matter of discussion. |
doi_str_mv | 10.1017/S0007114512004382 |
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Under the EURopean micronutrient RECommendations Aligned (EURRECA) consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a database that includes ‘best practice’ guidelines which can be used as a resource by future panels when setting micronutrient recommendations. As part of this process, the objective of the present study was to undertake a systematic review and meta-analysis of previously published data describing the relationship between Zn intake and status in adults. Searches were performed of literature published up to February 2010 using MEDLINE, Embase and the Cochrane Library. Data extracted included population characteristics, dose of Zn, duration of study, dietary intake of Zn, and mean concentration of Zn in plasma or serum at the end of the intervention period. An intake–status regression coefficient ($\circ {>\beta }$) was estimated for each individual study, and pooled meta-analysis undertaken. The overall pooled $\circ {>\beta }$ for Zn supplementation on serum/plasma Zn concentrations from randomised controlled trials and observational studies was 0·08 (95 % CI 0·05, 0·11; P < 0·0001; I2 84·5 %). An overall $\circ {>\beta }$ of 0·08 means that for every doubling in Zn intake, the difference in Zn serum or plasma concentration is $2^{ \circ {>\beta }}$ (20·08 = 1·06), which is 6 %. Whether the dose–response relationship, as provided in the present paper, could be used as either qualitative or quantitative evidence to substantiate the daily Zn intake dose necessary to achieve normal or optimal levels of biomarkers for Zn status remains a matter of discussion.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114512004382</identifier><identifier>PMID: 23244547</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; age ; Aged ; Biological and medical sciences ; Biomarkers ; Cohort analysis ; Consortia ; Cross-sectional studies ; Diet ; Diet - adverse effects ; Dietary Supplements ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Hair ; Heterogeneity ; Humans ; Leukocytes ; Male ; men ; Meta-analysis ; metabolism ; Nutrition research ; Nutritional Requirements ; Nutritional Status ; Observational studies ; Plasma ; population ; Population characteristics ; Practice Guidelines as Topic ; Reproducibility of Results ; sex ; supplementation ; Systematic review ; Systematic Review with Meta-analysis ; Urine ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; women ; zenith ; Zinc ; Zinc - administration & dosage ; Zinc - blood ; Zinc - deficiency</subject><ispartof>British journal of nutrition, 2012-12, Vol.108 (11), p.1962-1971</ispartof><rights>Copyright © The Authors 2012</rights><rights>2014 INIST-CNRS</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-209fb201a22403df003f6fa34ea2b0739346274abdff6b6317d737d64fff2cd93</citedby><cites>FETCH-LOGICAL-c563t-209fb201a22403df003f6fa34ea2b0739346274abdff6b6317d737d64fff2cd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114512004382/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,72960</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26756713$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23244547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lowe, Nicola M.</creatorcontrib><creatorcontrib>Medina, Marisol Warthon</creatorcontrib><creatorcontrib>Stammers, Anna-Louise</creatorcontrib><creatorcontrib>Patel, Sujata</creatorcontrib><creatorcontrib>Souverein, Olga W.</creatorcontrib><creatorcontrib>Dullemeijer, Carla</creatorcontrib><creatorcontrib>Serra-Majem, Lluis</creatorcontrib><creatorcontrib>Nissensohn, Mariela</creatorcontrib><creatorcontrib>Hall Moran, Victoria</creatorcontrib><title>The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Dietary Zn recommendations vary widely across Europe due to the heterogeneity of approaches used by expert panels. Under the EURopean micronutrient RECommendations Aligned (EURRECA) consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a database that includes ‘best practice’ guidelines which can be used as a resource by future panels when setting micronutrient recommendations. As part of this process, the objective of the present study was to undertake a systematic review and meta-analysis of previously published data describing the relationship between Zn intake and status in adults. Searches were performed of literature published up to February 2010 using MEDLINE, Embase and the Cochrane Library. Data extracted included population characteristics, dose of Zn, duration of study, dietary intake of Zn, and mean concentration of Zn in plasma or serum at the end of the intervention period. An intake–status regression coefficient ($\circ {>\beta }$) was estimated for each individual study, and pooled meta-analysis undertaken. The overall pooled $\circ {>\beta }$ for Zn supplementation on serum/plasma Zn concentrations from randomised controlled trials and observational studies was 0·08 (95 % CI 0·05, 0·11; P < 0·0001; I2 84·5 %). An overall $\circ {>\beta }$ of 0·08 means that for every doubling in Zn intake, the difference in Zn serum or plasma concentration is $2^{ \circ {>\beta }}$ (20·08 = 1·06), which is 6 %. Whether the dose–response relationship, as provided in the present paper, could be used as either qualitative or quantitative evidence to substantiate the daily Zn intake dose necessary to achieve normal or optimal levels of biomarkers for Zn status remains a matter of discussion.</description><subject>Adult</subject><subject>age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Cohort analysis</subject><subject>Consortia</subject><subject>Cross-sectional studies</subject><subject>Diet</subject><subject>Diet - adverse effects</subject><subject>Dietary Supplements</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hair</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Male</subject><subject>men</subject><subject>Meta-analysis</subject><subject>metabolism</subject><subject>Nutrition research</subject><subject>Nutritional Requirements</subject><subject>Nutritional Status</subject><subject>Observational studies</subject><subject>Plasma</subject><subject>population</subject><subject>Population characteristics</subject><subject>Practice Guidelines as Topic</subject><subject>Reproducibility of Results</subject><subject>sex</subject><subject>supplementation</subject><subject>Systematic review</subject><subject>Systematic Review with Meta-analysis</subject><subject>Urine</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>women</subject><subject>zenith</subject><subject>Zinc</subject><subject>Zinc - administration & dosage</subject><subject>Zinc - blood</subject><subject>Zinc - deficiency</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1UU1u1DAUthCIDgMHYIMsoUpsQv2XeKa7ajT8SBVIpV1bL8lz6zZxgp0wGlbcgQtwNk6CMzNUCMTGT9b3az9CnnP2mjOuTz4xxjTnKueCMSUX4gGZcaXzTBSFeEhmE5xN-BF5EuNtui44Wz4mR0IKpXKlZ-TH5Q3SgA0MrvPxxvW0xGGD6OlX5yvq_AB3SMHXNGIY25O-gdjCHqw6X6Efwk6bqBTqsRniKQUat3HANgFVMv_icLOzqLuIP799Dxj7FIa0xQEy8NBso4u03NIhlVlfXVysV2f0Q-rRhbun5JGFJuKzw5yTqzfry9W77Pzj2_ers_Osygs5ZIItbSkYByEUk7VlTNrCglQIomRaLqUqhFZQ1tYWZSG5rrXUdaGstaKql3JOTve-G7hG73w6jIdQuWg6cKZxZYCwNZsxGN9Mox_LaJRUXMokfrUX96H7PGIcTOtihU0DHrsxGp5KLZaLRao2Jy__ot52Y0h_sGPxZCfEZMj3rCp0MQa0pg-unQpwZqbdm392nzQvDs5j2WJ9r_i97EQ4PhAgVtDYAH563j2v0Hmh-RQuD-HQlsHV1_hHx__G_wKd-8mC</recordid><startdate>20121214</startdate><enddate>20121214</enddate><creator>Lowe, Nicola M.</creator><creator>Medina, Marisol Warthon</creator><creator>Stammers, Anna-Louise</creator><creator>Patel, Sujata</creator><creator>Souverein, Olga W.</creator><creator>Dullemeijer, Carla</creator><creator>Serra-Majem, Lluis</creator><creator>Nissensohn, Mariela</creator><creator>Hall Moran, Victoria</creator><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>QVL</scope></search><sort><creationdate>20121214</creationdate><title>The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network</title><author>Lowe, Nicola M. ; Medina, Marisol Warthon ; Stammers, Anna-Louise ; Patel, Sujata ; Souverein, Olga W. ; Dullemeijer, Carla ; Serra-Majem, Lluis ; Nissensohn, Mariela ; Hall Moran, Victoria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-209fb201a22403df003f6fa34ea2b0739346274abdff6b6317d737d64fff2cd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Cohort analysis</topic><topic>Consortia</topic><topic>Cross-sectional studies</topic><topic>Diet</topic><topic>Diet - adverse effects</topic><topic>Dietary Supplements</topic><topic>Feeding. 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Academic</collection><collection>NARCIS:Publications</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lowe, Nicola M.</au><au>Medina, Marisol Warthon</au><au>Stammers, Anna-Louise</au><au>Patel, Sujata</au><au>Souverein, Olga W.</au><au>Dullemeijer, Carla</au><au>Serra-Majem, Lluis</au><au>Nissensohn, Mariela</au><au>Hall Moran, Victoria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2012-12-14</date><risdate>2012</risdate><volume>108</volume><issue>11</issue><spage>1962</spage><epage>1971</epage><pages>1962-1971</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Dietary Zn recommendations vary widely across Europe due to the heterogeneity of approaches used by expert panels. Under the EURopean micronutrient RECommendations Aligned (EURRECA) consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a database that includes ‘best practice’ guidelines which can be used as a resource by future panels when setting micronutrient recommendations. As part of this process, the objective of the present study was to undertake a systematic review and meta-analysis of previously published data describing the relationship between Zn intake and status in adults. Searches were performed of literature published up to February 2010 using MEDLINE, Embase and the Cochrane Library. Data extracted included population characteristics, dose of Zn, duration of study, dietary intake of Zn, and mean concentration of Zn in plasma or serum at the end of the intervention period. An intake–status regression coefficient ($\circ {>\beta }$) was estimated for each individual study, and pooled meta-analysis undertaken. The overall pooled $\circ {>\beta }$ for Zn supplementation on serum/plasma Zn concentrations from randomised controlled trials and observational studies was 0·08 (95 % CI 0·05, 0·11; P < 0·0001; I2 84·5 %). An overall $\circ {>\beta }$ of 0·08 means that for every doubling in Zn intake, the difference in Zn serum or plasma concentration is $2^{ \circ {>\beta }}$ (20·08 = 1·06), which is 6 %. Whether the dose–response relationship, as provided in the present paper, could be used as either qualitative or quantitative evidence to substantiate the daily Zn intake dose necessary to achieve normal or optimal levels of biomarkers for Zn status remains a matter of discussion.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>23244547</pmid><doi>10.1017/S0007114512004382</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult age Aged Biological and medical sciences Biomarkers Cohort analysis Consortia Cross-sectional studies Diet Diet - adverse effects Dietary Supplements Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Hair Heterogeneity Humans Leukocytes Male men Meta-analysis metabolism Nutrition research Nutritional Requirements Nutritional Status Observational studies Plasma population Population characteristics Practice Guidelines as Topic Reproducibility of Results sex supplementation Systematic review Systematic Review with Meta-analysis Urine Vertebrates: anatomy and physiology, studies on body, several organs or systems women zenith Zinc Zinc - administration & dosage Zinc - blood Zinc - deficiency |
title | The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network |
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