Endotoxin exposure as a major determinant of lung function decline in pig farmers

Exposure-response relationships for endotoxin as measured in dust and longitudinal decline in lung function were studied. A cohort of 171 pig farmers was followed over a 3-yr period. Long-term average exposure to dust and endotoxin was determined by personal monitoring in summer and winter, using da...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 1998, Vol.157 (1), p.15-18
Main Authors: VOGELZANG, P. F. J, VAN DER GULDEN, J. W. J, FOLGERING, H, KOLK, J. J, HEEDERIK, D, PRELLER, L, TIELEN, M. J. M, VAN SCHAYCK, C. P
Format: Article
Language:English
Subjects:
Adult
Agricultural Workers' Diseases - etiology
Agricultural Workers' Diseases - physiopathology
Animal Husbandry
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Dust
Endotoxins - adverse effects
Environmental and Occupational Health Group
Environmental Monitoring
Follow-Up Studies
Forced Expiratory Volume
Humans
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Lung Diseases - etiology
Lung Diseases - physiopathology
Medical sciences
Occupational Exposure - adverse effects
Seasons
Surveys and Questionnaires
Swine
Toxicology
Vakgroep Gezondheidsleer
Vital Capacity
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Summary:Exposure-response relationships for endotoxin as measured in dust and longitudinal decline in lung function were studied. A cohort of 171 pig farmers was followed over a 3-yr period. Long-term average exposure to dust and endotoxin was determined by personal monitoring in summer and winter, using data on farm characteristics and activities. Mean decline in FEV1 was 73 ml/yr and in FVC 55 ml/ yr. Long-term average exposure to dust was 2.63 mg/m3 (geometric SD [GSD] 1.30), and to endotoxin, 105 ng/m3 (GSD 1.5). Annual decline in FEV1 was significantly associated with endotoxin exposure. An increase in exposure with a factor 2 was associated with an extra decline of FEV1 of 19 ml/yr.
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.157.1.9703087