Intermittent stimulus presentation stabilizes neuronal responses in macaque area MT

• Published in: Journal of neurophysiology 2012-10, Vol.108 (8), p.2101-2114
• Main Authors: Klink, P Christiaan, Oleksiak, Anna, Lankheet, Martin J M, van Wezel, Richard J A
• Format: Article
• Language: English
• Subjects: adaptation; ambiguous patterns; Animals; attention; binocular-rivalry; brain; Evoked Potentials, Visual; local-field potentials; Macaca mulatta; Male; Neural Pathways; perceptual memory; Photic Stimulation; primary visual-cortex; Sensory Receptor Cells - classification; Sensory Receptor Cells - physiology; structure-from-motion; variability; Visual Cortex - cytology; Visual Cortex - physiology; Visual Perception
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00252.2012

Repeated stimulation impacts neuronal responses. Here we show how response characteristics of sensory neurons in macaque visual cortex are influenced by the duration of the interruptions during intermittent stimulus presentation. Besides effects on response magnitude consistent with neuronal adaptation, the response variability was also systematically influenced. Spike rate variability in motion-sensitive area MT decreased when interruption durations were systematically increased from 250 to 2,000 ms. Activity fluctuations between subsequent trials and Fano factors over full response sequences were both lower with longer interruptions, while spike timing patterns became more regular. These variability changes partially depended on the response magnitude, but another significant effect that was uncorrelated with adaptation-induced changes in response magnitude was also present. Reduced response variability was furthermore accompanied by changes in spike-field coherence, pointing to the possibility that reduced spiking variability results from interactions in the local cortical network. While neuronal response stabilization may be a general effect of repeated sensory stimulation, we discuss its potential link with the phenomenon of perceptual stabilization of ambiguous stimuli as a result of interrupted presentation.