Inter-ethnic differences in genetic variants within the transmembrane protease, serine 6 (TMPRSS6) gene associated with iron status indicators: a systematic review with meta-analyses

Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more...

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Bibliographic Details
Published in:Genes & nutrition 2015-01, Vol.10 (1), p.442-442, Article 442
Main Authors: Gichohi-Wainaina, Wanjiku N, Towers, G. Wayne, Swinkels, Dorine W, Zimmermann, Michael B, Feskens, Edith J, Melse-Boonstra, Alida
Format: Article
Language:English
Subjects:
African Americans
alleles
ancestry
anemia
Asians
blood serum
caucasian populations
common variants
deficiency anemia
ferritin
gene frequency
genome-wide association
hepcidin
iron
matriptase-2 tmprss6
meta-analysis
metabolism
nutrient deficiencies
proteinases
racial-differences
Research Paper
serine
serum hepcidin
single nucleotide polymorphism
systematic review
transferrin
transferrin saturation
united-states
Whites
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Summary:Transmembrane protease, serine 6 (TMPRSS6), is likely to be involved in iron metabolism through its pleiotropic effect on hepcidin concentrations. Recently, genome-wide association studies have identified common variants in the TMPRSS6 gene to be linked to anaemia and low iron status. To get a more precise evaluation of identified TMPRSS6 single nucleotide polymorphism associations with iron status in cohorts of differing continental ancestry, we conducted a systematic review with meta-analyses. We searched the literature using HuGE Navigator, Pubmed and Scopus databases for primarily genome-wide association studies using TMPRSS6 as a free term. Fixed-effects meta-analysis was used to obtain summary estimates of associations. Eleven studies comprised Caucasian populations, four included an Asian population and one study included an African-American population. Differences in minor allele frequencies of 8 TMPRSS6 SNPs (rs855791, rs4820268, rs2111833, rs1421312, rs228921, rs228918, rs228919 and rs575620) across ethnic groups were observed, with the MAF of rs855791 significantly higher in Asian populations than in Caucasians (0.55 vs 0.42, P 
ISSN:1555-8932
1865-3499
DOI:10.1007/s12263-014-0442-2