Chemical analysis of estragole in fennel based teas and associated safety assessment using the Margin of Exposure (MOE) approach

•A safety assessment of estragole in fennel based teas was performed.•Infusions from whole fennel fruits contained lower levels of estragole compared to infusions from fine cut fennel material.•For adults MOEs were generally >10,000 indicating a low priority for risk management.•MOEs for use of f...

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Bibliographic Details
Published in:Food and chemical toxicology 2014-03, Vol.65, p.147-154
Main Authors: van den Berg, Suzanne J.P.L., Alhusainy, Wasma, Restani, Patrizia, Rietjens, Ivonne M.C.M.
Format: Article
Language:English
Subjects:
Adult
Anisoles - chemistry
Anisoles - toxicity
Biological and medical sciences
Environmental Exposure
essential oils
Estragole
Fennel tea
Foeniculum - chemistry
foeniculum-vulgare
fruits
Humans
Infant
Margin of Exposure (MOE)
Medical sciences
methyl eugenol
risk
Safety assessment
supplements
Tea - chemistry
Toxicology
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Summary:•A safety assessment of estragole in fennel based teas was performed.•Infusions from whole fennel fruits contained lower levels of estragole compared to infusions from fine cut fennel material.•For adults MOEs were generally >10,000 indicating a low priority for risk management.•MOEs for use of fennel teas marketed for children were generally
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2013.12.035