Exercise training improves liver steatosis in mice

Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which seems to lower steatosis partly independent of weight loss. However, limited data are availabl...

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Bibliographic Details
Published in:Nutrition & metabolism 2015-08, Vol.12 (1), p.29-29, Article 29
Main Authors: Alex, Sheril, Boss, Andreas, Heerschap, Arend, Kersten, Sander
Format: Article
Language:English
Subjects:
Care and treatment
Chair Nutrition Metabolism and Genomics
Choline
Dextrose
Fatty acids
Glucose
Glycogen
HNE Nutrition, Metabolism and Genomics
HNE Voeding, Metabolisme en Genomics
Liver
Liver diseases
Metabolism
Nutrition
Nutrition, Metabolism and Genomics
Obesity
Physiological aspects
Triglycerides
VLAG
Voeding, Metabolisme en Genomica
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Summary:Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which seems to lower steatosis partly independent of weight loss. However, limited data are available about the mechanisms involved. The aim of the present study was to identify the mechanisms underlying the effect of regular exercise on liver steatosis. Non-obese male mice were rendered steatotic by feeding a sucrose-enriched choline-deficient diet. They were then subjected to daily treadmill running for three weeks, whereas the control mice remained sedentary. Compared to the untrained mice, trained mice showed similar adipose tissue mass but had significantly reduced size of lipid droplets in the liver coupled with a reduction in liver triglyceride content (~30 %, P 
ISSN:1743-7075
1743-7075
DOI:10.1186/s12986-015-0026-1