Kidney dysfunction, systemic inflammation and mental well-being in elderly post-myocardial infarction patients

The aim was to investigate whether mild kidney dysfunction and low-grade inflammation in post-myocardial infarction patients are independently associated with markers of mental well-being (i.e. depressive and apathy symptoms, and dispositional optimism). In post-myocardial infarction patients, kidne...

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Bibliographic Details
Published in:BMC Psychology 2017-01, Vol.5 (1), p.1-1, Article 1
Main Authors: Heeres, Rick H M, Hoogeveen, Ellen K, Geleijnse, Johanna M, de Goede, Janette, Kromhout, Daan, Giltay, Erik J
Format: Article
Language:English
Subjects:
Afdeling Humane voeding
Aged
Aged patients
Aged, 80 and over
Analysis
Apathy
Chair Nutrition and Disease
Complications and side effects
Cross-Sectional Studies
Depressive Disorder - epidemiology
Female
Health aspects
Heart attack
HNE Nutrition and Disease
HNE Voeding en Ziekte
Human Nutrition
Human Nutrition & Health
Human Nutrition (HNE)
Humane Voeding
Humane Voeding & Gezondheid
Humans
Inflammation
Inflammation - epidemiology
Inflammation - psychology
Kidney Diseases - epidemiology
Kidney Diseases - psychology
Kidney failure
Male
Mental Health
Middle Aged
Myocardial Infarction - epidemiology
Myocardial Infarction - psychology
Nutrition and Disease
Optimism
Psychological aspects
Risk factors
VLAG
Voeding en Ziekte
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Summary:The aim was to investigate whether mild kidney dysfunction and low-grade inflammation in post-myocardial infarction patients are independently associated with markers of mental well-being (i.e. depressive and apathy symptoms, and dispositional optimism). In post-myocardial infarction patients, kidney function was assessed by estimated glomerular filtration rate (eGFR) calculated from the combined CKD-EPI formula based on serum levels of both creatinine and cystatine C. Systemic inflammation was assessed using high sensitivity C-reactive protein (hs-CRP) levels. The 15-item Geriatric Depression Scale (GDS-15), the 3-item apathy subscale and the 4-item optimism questionnaire (4Q) were used to measure mental well-being and were analyzed using linear multivariable regression analysis. Of the 2355 patients, mean age was 72.3 (range 63-84) years and 80.1% were men. After multivariable adjustment, a poorer kidney function was associated with more depressive symptoms (β = -0.084, p 
ISSN:2050-7283
2050-7283
DOI:10.1186/s40359-016-0170-z