Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome and 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restrict...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2008-06, Vol.21 (3), p.188-192
Main Authors: XU, Ling-Ling, XIANG, Hong-Ding, QIU, Chang-Chun, XU, Qun
Format: Article
Language:English
Subjects:
临床分析
代谢综合征
多形态
治疗方法
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Summary:Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome and 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism analysis. Results The allelic frequency of the Leu72Met polymorphism was 17.3% in the patient group and 11.9% in the control group （x^2=7.36, P=0.007）. Metabolic syndrome was more prevalent among carriers of the Met72 variant （43.8 vs 33.1%, age- and sex-adjusted odds ratio=1.57, P=0.01）. No Arg51Gln variants were found in our study subjects. Conclusion Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Han Nationality Chinese.
ISSN:0895-3988
2214-0190
DOI:10.1016/S0895-3988(08)60027-6