Characterization of Salmonella Enterica Serotype Typhimurium from Outpatients of 28 Hospitals in Henan Province in 2006

• Published in: Biomedical and environmental sciences 2009-04, Vol.22 (2), p.136-140
• Main Authors: ZHU, Min, XIE, Zhi-Qiang, ZHANG, Li-Shi, XIA, Sheng-Li, YANG, Wei-Zhong, RAN, Lu, WANG, Zi-Jun
• Format: Article
• Language: English
• Subjects: Adult; Anti-Bacterial Agents - pharmacology; Child; Child, Preschool; China - epidemiology; Ciprofloxacin; Diarrhea - microbiology; Female; Humans; Infant; Male; Middle Aged; Multidrug-Resistant; Outpatients; Pulsed-field gel electrophoresis; Salmonella Infections - epidemiology; Salmonella Infections - microbiology; Salmonella typhimurium; Salmonella typhimurium - classification; Salmonella typhimurium - drug effects; Young Adult; 伤寒杆菌; 医院门诊; 河南省; 环丙沙星; 脉冲场凝胶电泳; 腹泻患者; 鼠伤寒沙门氏菌
• ISSN: 0895-3988; 2214-0190
• DOI: 10.1016/S0895-3988(09)60036-2

Objective To characterize the diarrheal patients with Salmonella typhimurium （S. typhimurium） infections and to set up the first baseline for S. typhimuri_um pulsed-field gel electrophoresis （PFGE） patterns in Henan province, thus laying a foundation for comprehensive surveillance of Salmonella in human as well as foods. Methods S. typhimurium isolates recovered from outpatients with diarrhea in Henan province from May to October of 2006 were characterized. Antimicrobial susceptibility tests of 8 antimicrobial agents and PFGE were carried out to analyze the S. typhimurium isolates. Results Twenty-four （0.9%） S. typhimurium isolates were identified from 2661 stool specimens of diarrheal cases. Eighty-eight percent of isolates showed resistance to at least one antimicrobial agent. The resistance to chloramphenicol （79%） was most common. Fifty-eight percent of isolates were resistant to ciprofloxacin. All the 14 ciprofloxacin-resistant isolates were resistant to more than five antimicrobial agents. Thirty-three percent of S. typhimurium isolates were resistant to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline （R-type ACSSuT）. Eight antimicrobia-resistant phenotypes were found among the 24 isolates in 16 PFGE patterns. Conclusion The rate of multidrug-resistant S. typhimurium is relatively high in S. typhimurium PFGE patterns of Henan province. Multidrug-resistant S. typhimurium should be considered a public health threat.