A Study on the Protective Effect of Cynodon dactylon Leaves Extract in Diabetic Rats

• Published in: Biomedical and environmental sciences 2011-04, Vol.24 (2), p.190-199
• Main Authors: Karthik, D, Ravikumar, S
• Format: Article
• Language: English
• Subjects: Alloxan diabetes; Animals; Antidiabetic; Antioxidant; Antioxidants - metabolism; Blood Glucose - drug effects; Body Weight - drug effects; Cynodon - chemistry; Cynodon dactylon; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - drug therapy; Enzyme profile; Enzymes - blood; Ethanolic extract; GC-MS; Heart - anatomy & histology; Heart - drug effects; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Kidney - anatomy & histology; Kidney - drug effects; Lipid profile; Lipids - blood; Liver - anatomy & histology; Liver - drug effects; Male; Molecular Structure; Organ Size; Phytotherapy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Rats; Rats, Wistar; Spleen - anatomy & histology; Spleen - drug effects; VLDL; 保护作用; 叶提取物; 四氧嘧啶; 实验性糖尿病; 狗牙根; 糖尿病大鼠; 高密度脂蛋白胆固醇
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/0895-3988.2011.02.014

Objective To investigate the antidiabetic, antioxidant and hypolipidemic efficacy of Cynodon dactylon in diabetic rats. Methods The experimental rats were randomly divided into three groups： Group I： control; Group II： Alloxan diabetic, untreated; and Group III： Alloxan diabetic treated with ethanolic extract of C. dactylon leaves （450 mg/kg bw）. Experimental diabetes was induced by alloxan in a single dose of 150 mg/kg bw. Results A Significant diminution of fasting blood sugar level was observed and also significant increase in HDL and decrease （P0.05） in cholesterol, triglyceride, LDL and VLDL were observed after 15 days of treatment. The investigation also revealed, the activities of AST, ALT, ALP, AP, LDH, and CPK （P0.05） were decreased in the extract‐supplemented group. The significant decrease in protein content and SOD, CAT, GPx, and GSH （P0.05） activity and increase in LPO in plasma were found to be ameliorated after treatment. Conclusion Our result supports the fact that administration of extract of C. dactylon leave is able to reduce hyperglycemia and hyperlipidemia risk and also reduced the oxidative stress in diabetic rats.