The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats

Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2013-07, Vol.26 (7), p.625-628
Main Authors: BAI, Ya Na, MA, Li, WANG, Qiu Ying, PU, Hong Quan, ZHANG, Xiao Pei, WU, Xi Jiang, XUAN, Xiao Qiang, CHENG, Ning
Format: Article
Language:English
Subjects:
Acute Lung Injury - chemically induced
Acute Lung Injury - metabolism
Acute Lung Injury - pathology
Animals
CDC2 Protein Kinase - genetics
CDC2 Protein Kinase - metabolism
Cell Cycle - drug effects
Checkpoint Kinase 1
Female
Lung - metabolism
Lung - pathology
Lung - ultrastructure
Male
Malondialdehyde - metabolism
Microscopy, Electron, Transmission
Organometallic Compounds - toxicity
Oxidative Stress
Protein Kinases - genetics
Protein Kinases - metabolism
Rats
Rats, Sprague-Dawley
RNA, Messenger - metabolism
一氧化碳
动物实验
大鼠
急性
损伤机制
羰基镍
肺炎
金属化合物
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Summary:Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs[1]. However, few studies have investigated nickel carbonyl poisoning in humans.
ISSN:0895-3988
2214-0190
DOI:10.3967/0895-3988.2013.07.018