Effect of Cadmium on Rat Leydig Cell Testosterone Production and DNA Integrity in vitro

Cadmium （Cd） is an elemental heavy metal with widely recognized toxicity. Its long-term use in industrial processes and daily activities has caused alarming levels of Cd contamination in the natural environment. According to the estimates by the Agency of Toxic Substances and Disease Registry in the...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2013-09, Vol.26 (9), p.769-773
Main Authors: LIU, Qing, GU, Jian Hong, YUAN, Yan, LIU, Xue Zhong, WANG, Ya Jun, WANG, Han Dong, LIU, Zong Ping, WANG, Zong Yuan, BIAN, Jian Chun
Format: Article
Language:English
Subjects:
3-Hydroxysteroid Dehydrogenases - metabolism
Animals
Cadmium - toxicity
Cells, Cultured
DNA
DNA - drug effects
DNA Damage
Leydig Cells - drug effects
Leydig Cells - enzymology
Leydig Cells - secretion
Male
Rats
Testosterone - biosynthesis
Testosterone - secretion
大鼠
整性
睾丸
睾酮
细胞分泌
镉（Cd）
间质
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Summary:Cadmium （Cd） is an elemental heavy metal with widely recognized toxicity. Its long-term use in industrial processes and daily activities has caused alarming levels of Cd contamination in the natural environment. According to the estimates by the Agency of Toxic Substances and Disease Registry in the US, 25 000 to 30 000 metric tons of Cd is annually released to the environment . Results of previous studies have demonstrated that several organs are targets of Cd, but the most important of these targeted organs may be the testes.
ISSN:0895-3988
2214-0190
DOI:10.3967/0895-3988.2013.09.009