Immunotoxicity of Acrylamide in Female BALB/c Mice

Objective To investigate the immunotoxicity of acrylamide （ACR） in female BALB/c mice. Methods A total of 200 female mice weighing 18-22 g were randomly divided into four clusters based on body weight, and each weight-based cluster included five groups （10 mice per group）： negative control, positive...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2014-06, Vol.27 (6), p.401-409
Main Authors: FANG, Jin, LIANG, Chun Lai, JIA, Xu Dong, LI, Ning
Format: Article
Language:English
Subjects:
Acrylamide - toxicity
Acrylamide(ACR)
Animals
Body Weight - drug effects
CD4-CD8 Ratio
Cytokines - blood
Female
Female BALB/c mice
Immunity, Cellular - drug effects
Immunity, Humoral - drug effects
Immunophenotyping
Immunotoxicity
Immunotoxins - toxicity
Mice
Mice, Inbred BALB C
Organ Size - drug effects
Random Allocation
Spleen - drug effects
Thymus Gland - drug effects
Toxicity Tests
丙烯酰胺
免疫抑制作用
免疫毒性
淋巴细胞
白细胞介素-6
细胞免疫
雌性小鼠
非特异性免疫
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Summary:Objective To investigate the immunotoxicity of acrylamide （ACR） in female BALB/c mice. Methods A total of 200 female mice weighing 18-22 g were randomly divided into four clusters based on body weight, and each weight-based cluster included five groups （10 mice per group）： negative control, positive control （cyclophosphamide）, low, intermediate, and high dose ACR groups, and all the groups were administered ACR by gavage for 30 days. At the end of the study, the immunotoxicological effects of the ACR were evaluated through immunopathology, humoral immunity, cellular immunity, and non-specific immunity. Results The terminal body weight, spleen and thymus weights, lymphocyte counts in the ACR-H group were decreased, pathological changes were observed in lymph glands, thymus and spleen. %T cells in blood lymphocytes were significantly increased in all ACR-treated groups, and a significant reduction of % natural killer（NK） cells and increase of %Th cells were observed in the ACR-H group. interleukin-6（IL-6）, Concanavalin A（ConA）-induced splenocyte proliferation and serum half hemolysis value （HCso） were also significantly suppressed in the ACR-H group. Conclusion ACR elicited an inhibitory effect on cellular and humoral immunity of mice after 30 day feeding.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2014.069