Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese： a Case-control Study

• Published in: Biomedical and environmental sciences 2015-07, Vol.28 (7), p.510-517
• Main Authors: YOU, Hai Fei, ZHAO, Jing Zhi, ZHAI, Yu Jia, YIN, Lei, PANG, Chao, LUO, Xin Ping, ZHANG, Ming, WANG, Jin Jin, LI, Lin Lin, WANG, Yan, WANG, Qian, WANG, Bing Yuan, REN, Yong Cheng, HU, Dong Sheng
• Format: Article
• Language: English
• Subjects: 2型糖尿病; Asian Continental Ancestry Group - genetics; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Female; Gene polymorphism; Haplotype; Haplotypes; Humans; Logistic Models; Logistic回归; Low Density Lipoprotein Receptor-Related Protein-5 - genetics; Low-density lipoprotein receptor-related protein 5; Male; Metabolic characteristics; Middle Aged; Odds Ratio; PCR-RFLP方法; Polymorphism, Single Nucleotide; Rural Population; Triglycerides - blood; Type 2 diabetes mellitus; 低密度脂蛋白; 受体相关蛋白; 基因多态性; 汉族; 病例
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/bes2015.073

Objective To investigate the association between low-density lipoprotein receptor-related protein 5 （LRPS） variants （rs12363572 and rs4930588） and type 2 diabetes mellitus （T2DM） in Han Chinese. Methods A total of 1842 T2DM cases （507 newly diagnosed cases and 1335 previously diagnosed cases） and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms （SNPs）. Odds ratios （ORs） and 95% confidence intervals （95% CIs） were calculated to describe the strength of the association by logistic regression. Results In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index （BMI）, the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype ~ was associated with reduced risk of T2DM （OR 0.820, 95% CI 0.732-0.919）. In addition, rs12363572 was associated with BMI （P〈0.001） and rs4930588 was associated with triglyceride levels （P=0.043） in 507 newly diagnosed T2DM cases but not in healthy controls. Conclusion No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.