C-reactive Protein Level,Apolipoprotein B-to-apolipoprotein A-1 Ratio,and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China

• Published in: Biomedical and environmental sciences 2016-07, Vol.29 (7), p.467-474
• Main Authors: TIAN, Yun Fan, ZHOU, Yi Peng, ZHONG, Chong Ke, BUREN, Batu, XU, Tian, LI, Hong Mei, ZHANG, Ming Zhi, WANG, Ai Li, ZHANG, Yong Hong
• Format: Article
• Language: English
• Subjects: Adult; Apolipoprotein B-to-apolipoprotein A-1 ratio; Apolipoproteins A - classification; Apolipoproteins A - genetics; Apolipoproteins A - metabolism; Apolipoproteins B - genetics; Apolipoproteins B - metabolism; C-reactive protein; C-Reactive Protein - genetics; C-Reactive Protein - metabolism; Cohort Studies; Coronary Disease - epidemiology; Coronary Disease - etiology; Coronary heart disease; Gene Expression Regulation; Humans; Ischemic stroke; Mongolia - epidemiology; Prospective Studies; Risk Factors; Stroke - epidemiology; Stroke - etiology; Young Adult
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/bes2016.062

Objective We aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1（ApoB/ApoA-1） ratio on the incidence of ischemic stroke（IS） or coronary heart disease（CHD） in a Mongolian population in China.Methods From June 2003 to July 2012,2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation.All the participants were divided into four subgroups according to C-reactive protein（CRP） level and ApoB/ApoA-1 ratio.Cox proportional hazard models were used to estimate the hazard ratios（HRs） and 95% confidence intervals（CIs） for the IS and CHD events in all the subgroups.Results The HRs（95% CI） for IS and CHD were 1.33（0.84-2.12）,1.14（0.69-1.88）,and 1.91（1.17-3.11） in the ‘low CRP level with high ApoB/ApoA-1＇,‘high CRP level with low ApoB/ApoA-1＇,and ‘high CRP level with high ApoB/ApoA-1＇ subgroups,respectively,in comparison with the ‘low CRP level with low ApoB/ApoA-1＇ subgroup.The risks of IS and CHD events was highest in the ‘high CRP level with high ApoB/ApoA-1＇ subgroup,with statistical significance.Conclusion High CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population.This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.