DNA Methylation and Birth Weight： a Genome-wide Analysis

The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite‐converted DNA. We have identifie...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2017-09, Vol.30 (9), p.667-670
Main Authors: MAO, Li Li, XIAO, Xin Hua, ZHANG, Qian, ZHENG, Jia, LI, Wen Hui, YU, Miao, ZHANG, Hua Bing, PING, Fan, XU, Jian Ping, WANG, Xiao Jing
Format: Article
Language:English
Subjects:
dna甲基化
MAPK信号通路
亚硫酸氢盐
信号转导通路
出生体重
基因组分析
胎儿发育
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Summary:The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite‐converted DNA. We have identified many differentially methylated Cp G sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin‐signaling pathway（ISP）, adipocytokine signaling pathway（ASP） and MAPK signaling pathway are involved in the fetal programming of diabetes.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2017.088