MMP Inhibitor Ilomastat Improves Survival of Mice Exposed to γ-Irradiation

There is still a need for better protection against or mitigation of the effects of ionizing radiation following conventional radiotherapy or accidental exposure. The objective of our current study was to investigate the possible roles of matrix metalloproteinase inhibitor, ilomastat, in the protect...

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Bibliographic Details
Published in:Biomedical and environmental sciences 2018-06, Vol.31 (6), p.467-472
Main Authors: LI, Xiao Man, TAN, Yong, HUANG, Chun Qian, XU, Meng Chuan, LI, Qian, PAN, Dong, ZHAO, Bao Quan, HU, Bu Rong
Format: Article
Language:English
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Summary:There is still a need for better protection against or mitigation of the effects of ionizing radiation following conventional radiotherapy or accidental exposure. The objective of our current study was to investigate the possible roles of matrix metalloproteinase inhibitor, ilomastat, in the protection of mice from total body radiation (TBI), and the underlying protective mechanisms. Ilomastat treatment increased the survival of mice after TBI. Ilomastat pretreatment promoted recovery of hematological and immunological cells in mice after 6 Gy γ-ray TBI. Our findings suggest the potential of ilomastat to protect against or mitigate the effects of radiation.
ISSN:0895-3988
2214-0190
DOI:10.3967/bes2018.062