Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

[Display omitted] •Flow field difference across different scales is a key aspect that influence the scale-up process.•Strain physiological response to heterogeneous environment makes the scale-up more complicated.•Rational scale-up strategies depend on both flow field and physiological response. The...

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Bibliographic Details
Published in:Chinese journal of chemical engineering 2021-02, Vol.30 (2), p.178-184
Main Authors: Xia, Jianye, Wang, Guan, Fan, Meng, Chen, Min, Wang, Zeyu, Zhuang, Yingping
Format: Article
Language:English
Subjects:
Bioreactors
Fermentation
Gas–liquid flow
Kinetics
Scale-up
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Summary:[Display omitted] •Flow field difference across different scales is a key aspect that influence the scale-up process.•Strain physiological response to heterogeneous environment makes the scale-up more complicated.•Rational scale-up strategies depend on both flow field and physiological response. The production capability of a fermentation process is predominately determined by individual strains, which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains. Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process. We review these two aspects and address progress in strategies for scaling up fermentation processes. A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.
ISSN:1004-9541
2210-321X
DOI:10.1016/j.cjche.2020.12.004