Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis

Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively eval...

Full description

Saved in:
Bibliographic Details
Published in:Traditional medicine research 2020-01, Vol.5 (1), p.53-61
Main Authors: Wang, Jia, Zhu, Yang, Feng-Xi, Long, Luo, Li, Wu, Jinlin, Yu, Ting, Dong-Xin, Tang
Format: Article
Language:English
Subjects:
Chemotherapy
Colorectal cancer
Medicine
Meta-analysis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 61
container_issue 1
container_start_page 53
container_title Traditional medicine research
container_volume 5
creator Wang, Jia
Zhu, Yang
Feng-Xi, Long
Luo, Li
Wu, Jinlin
Yu, Ting
Dong-Xin, Tang
description Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively evaluate the effect of Astragalus injection in the adjuvant treatment of colorectal cancer. This study aimed to systematically evaluate the efficacy and safety of Astragalus injection as an adjuvant treatment for colorectal cancer. Methods: The Cochrane Library, VIP database, Wanfang database, and Chinese Academic Journal Full Text database were searched for potentially eligible articles from inception to December 15, 2018. Randomized controlled trials in which patients were diagnosed with colorectal cancer were included. Patients in the control group received chemotherapy alone or combined with other drugs, or chemotherapy combined with radiotherapy. Patients in the experimental group were treated with Astragalus injection combined with interventions in the control group. Results: A total of 8 articles were included. Compared with Western medicine alone, the Astragalus injection could improve the therapeutic effect (RR = 1.18, 95% CI (1.01, 1.38), P= 0.03), improved the quality of life of colorectal cancer patients (SMD = 1.18, 95% CI (0.86, 1.50), P
doi_str_mv 10.12032/TMR20191228151
format article
fullrecord <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_ctyxyj_e202001008</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>ctyxyj_e202001008</wanfj_id><sourcerecordid>ctyxyj_e202001008</sourcerecordid><originalsourceid>FETCH-LOGICAL-p147t-fc9ca739d9a15c004606401e080171e6b3bbf1154f3abf19a2ef562421233acf3</originalsourceid><addsrcrecordid>eNpNkE1LAzEQhoMoWGrPXgOePKzOTLK7XW-l-AUVQdZzmaZJ6bLdrUlW7b83UEEv8z6Hh-GdEeIS4QYJFN3WL28EWCHRFHM8ESPSqDJVler0H5-LSQgNABCQzksYiXoWoucNt0OQ266xJm77TnKQnOa6GT65izJ6y3FnE7neS9O3vU8it9JwZ6y_kyx3NnLGHbeHsA0X4sxxG-zkN8fi_eG-nj9li9fH5_lske1RlzFzpjJcqmpdMeYGQBdQaEALU8ASbbFSq5VDzLVTnKBisi4vSBOSUmycGovr494v7hx3m2XTDz51CEsTD9-HZmnTnQAIME3u1dHd-_5jsCH-yekVlCMVmtQPgnxhPQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2452512642</pqid></control><display><type>article</type><title>Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis</title><source>Publicly Available Content Database</source><creator>Wang, Jia ; Zhu, Yang ; Feng-Xi, Long ; Luo, Li ; Wu, Jinlin ; Yu, Ting ; Dong-Xin, Tang</creator><creatorcontrib>Wang, Jia ; Zhu, Yang ; Feng-Xi, Long ; Luo, Li ; Wu, Jinlin ; Yu, Ting ; Dong-Xin, Tang</creatorcontrib><description>Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively evaluate the effect of Astragalus injection in the adjuvant treatment of colorectal cancer. This study aimed to systematically evaluate the efficacy and safety of Astragalus injection as an adjuvant treatment for colorectal cancer. Methods: The Cochrane Library, VIP database, Wanfang database, and Chinese Academic Journal Full Text database were searched for potentially eligible articles from inception to December 15, 2018. Randomized controlled trials in which patients were diagnosed with colorectal cancer were included. Patients in the control group received chemotherapy alone or combined with other drugs, or chemotherapy combined with radiotherapy. Patients in the experimental group were treated with Astragalus injection combined with interventions in the control group. Results: A total of 8 articles were included. Compared with Western medicine alone, the Astragalus injection could improve the therapeutic effect (RR = 1.18, 95% CI (1.01, 1.38), P= 0.03), improved the quality of life of colorectal cancer patients (SMD = 1.18, 95% CI (0.86, 1.50), P &lt;0.001), inhibited leukopenia (RR = 0.55, 95% CI (0.42, 0.71),P&lt; 0.001), reduced neurotoxicity (RR = 0.43, 95% CI (0.34, 0.56), P &lt; 0.001), and reduced the incidence of nausea and vomiting (RR = 0.67, 95% CI (0.55, 0.80),P &lt; 0.001). Conclusion: Astragalus injection can reduce the toxicity and improve the efficiency of the conventional Western medicine in the treatment of colorectal cancer.</description><identifier>ISSN: 2413-3973</identifier><identifier>EISSN: 2413-3973</identifier><identifier>DOI: 10.12032/TMR20191228151</identifier><language>eng</language><publisher>Auckland: TMR Publishing Group</publisher><subject>Chemotherapy ; Colorectal cancer ; Medicine ; Meta-analysis</subject><ispartof>Traditional medicine research, 2020-01, Vol.5 (1), p.53-61</ispartof><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/ctyxyj-e/ctyxyj-e.jpg</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2452512642?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,44590</link.rule.ids></links><search><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Zhu, Yang</creatorcontrib><creatorcontrib>Feng-Xi, Long</creatorcontrib><creatorcontrib>Luo, Li</creatorcontrib><creatorcontrib>Wu, Jinlin</creatorcontrib><creatorcontrib>Yu, Ting</creatorcontrib><creatorcontrib>Dong-Xin, Tang</creatorcontrib><title>Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis</title><title>Traditional medicine research</title><description>Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively evaluate the effect of Astragalus injection in the adjuvant treatment of colorectal cancer. This study aimed to systematically evaluate the efficacy and safety of Astragalus injection as an adjuvant treatment for colorectal cancer. Methods: The Cochrane Library, VIP database, Wanfang database, and Chinese Academic Journal Full Text database were searched for potentially eligible articles from inception to December 15, 2018. Randomized controlled trials in which patients were diagnosed with colorectal cancer were included. Patients in the control group received chemotherapy alone or combined with other drugs, or chemotherapy combined with radiotherapy. Patients in the experimental group were treated with Astragalus injection combined with interventions in the control group. Results: A total of 8 articles were included. Compared with Western medicine alone, the Astragalus injection could improve the therapeutic effect (RR = 1.18, 95% CI (1.01, 1.38), P= 0.03), improved the quality of life of colorectal cancer patients (SMD = 1.18, 95% CI (0.86, 1.50), P &lt;0.001), inhibited leukopenia (RR = 0.55, 95% CI (0.42, 0.71),P&lt; 0.001), reduced neurotoxicity (RR = 0.43, 95% CI (0.34, 0.56), P &lt; 0.001), and reduced the incidence of nausea and vomiting (RR = 0.67, 95% CI (0.55, 0.80),P &lt; 0.001). Conclusion: Astragalus injection can reduce the toxicity and improve the efficiency of the conventional Western medicine in the treatment of colorectal cancer.</description><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Medicine</subject><subject>Meta-analysis</subject><issn>2413-3973</issn><issn>2413-3973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpNkE1LAzEQhoMoWGrPXgOePKzOTLK7XW-l-AUVQdZzmaZJ6bLdrUlW7b83UEEv8z6Hh-GdEeIS4QYJFN3WL28EWCHRFHM8ESPSqDJVler0H5-LSQgNABCQzksYiXoWoucNt0OQ266xJm77TnKQnOa6GT65izJ6y3FnE7neS9O3vU8it9JwZ6y_kyx3NnLGHbeHsA0X4sxxG-zkN8fi_eG-nj9li9fH5_lske1RlzFzpjJcqmpdMeYGQBdQaEALU8ASbbFSq5VDzLVTnKBisi4vSBOSUmycGovr494v7hx3m2XTDz51CEsTD9-HZmnTnQAIME3u1dHd-_5jsCH-yekVlCMVmtQPgnxhPQ</recordid><startdate>20200102</startdate><enddate>20200102</enddate><creator>Wang, Jia</creator><creator>Zhu, Yang</creator><creator>Feng-Xi, Long</creator><creator>Luo, Li</creator><creator>Wu, Jinlin</creator><creator>Yu, Ting</creator><creator>Dong-Xin, Tang</creator><general>TMR Publishing Group</general><general>Guihang Guiyang Hospital, Guiyang, 550025, China%First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, China</general><general>Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001</general><general>Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001%Guizhou TCM Inheritance and Innovation Team on Oncology, Guiyang, 550001</general><general>Guizhou University of Traditional Chinese Medicine, Guiyang, 550002, China</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20200102</creationdate><title>Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis</title><author>Wang, Jia ; Zhu, Yang ; Feng-Xi, Long ; Luo, Li ; Wu, Jinlin ; Yu, Ting ; Dong-Xin, Tang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p147t-fc9ca739d9a15c004606401e080171e6b3bbf1154f3abf19a2ef562421233acf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Medicine</topic><topic>Meta-analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Zhu, Yang</creatorcontrib><creatorcontrib>Feng-Xi, Long</creatorcontrib><creatorcontrib>Luo, Li</creatorcontrib><creatorcontrib>Wu, Jinlin</creatorcontrib><creatorcontrib>Yu, Ting</creatorcontrib><creatorcontrib>Dong-Xin, Tang</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Traditional medicine research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jia</au><au>Zhu, Yang</au><au>Feng-Xi, Long</au><au>Luo, Li</au><au>Wu, Jinlin</au><au>Yu, Ting</au><au>Dong-Xin, Tang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis</atitle><jtitle>Traditional medicine research</jtitle><date>2020-01-02</date><risdate>2020</risdate><volume>5</volume><issue>1</issue><spage>53</spage><epage>61</epage><pages>53-61</pages><issn>2413-3973</issn><eissn>2413-3973</eissn><abstract>Background: The combination of Chinese patent medicine Astragalus injection and Western medicine has achieved a certain clinical effect in colorectal cancer patients. However, due to the uneven basic conditions and research indicators of these clinical trials, it is difficult to comprehensively evaluate the effect of Astragalus injection in the adjuvant treatment of colorectal cancer. This study aimed to systematically evaluate the efficacy and safety of Astragalus injection as an adjuvant treatment for colorectal cancer. Methods: The Cochrane Library, VIP database, Wanfang database, and Chinese Academic Journal Full Text database were searched for potentially eligible articles from inception to December 15, 2018. Randomized controlled trials in which patients were diagnosed with colorectal cancer were included. Patients in the control group received chemotherapy alone or combined with other drugs, or chemotherapy combined with radiotherapy. Patients in the experimental group were treated with Astragalus injection combined with interventions in the control group. Results: A total of 8 articles were included. Compared with Western medicine alone, the Astragalus injection could improve the therapeutic effect (RR = 1.18, 95% CI (1.01, 1.38), P= 0.03), improved the quality of life of colorectal cancer patients (SMD = 1.18, 95% CI (0.86, 1.50), P &lt;0.001), inhibited leukopenia (RR = 0.55, 95% CI (0.42, 0.71),P&lt; 0.001), reduced neurotoxicity (RR = 0.43, 95% CI (0.34, 0.56), P &lt; 0.001), and reduced the incidence of nausea and vomiting (RR = 0.67, 95% CI (0.55, 0.80),P &lt; 0.001). Conclusion: Astragalus injection can reduce the toxicity and improve the efficiency of the conventional Western medicine in the treatment of colorectal cancer.</abstract><cop>Auckland</cop><pub>TMR Publishing Group</pub><doi>10.12032/TMR20191228151</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2413-3973
ispartof Traditional medicine research, 2020-01, Vol.5 (1), p.53-61
issn 2413-3973
2413-3973
language eng
recordid cdi_wanfang_journals_ctyxyj_e202001008
source Publicly Available Content Database
subjects Chemotherapy
Colorectal cancer
Medicine
Meta-analysis
title Astragalus injection as an adjuvant treatment for colorectal cancer: a meta-analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T21%3A44%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Astragalus%20injection%20as%20an%20adjuvant%20treatment%20for%20colorectal%20cancer:%20a%20meta-analysis&rft.jtitle=Traditional%20medicine%20research&rft.au=Wang,%20Jia&rft.date=2020-01-02&rft.volume=5&rft.issue=1&rft.spage=53&rft.epage=61&rft.pages=53-61&rft.issn=2413-3973&rft.eissn=2413-3973&rft_id=info:doi/10.12032/TMR20191228151&rft_dat=%3Cwanfang_jour_proqu%3Ectyxyj_e202001008%3C/wanfang_jour_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p147t-fc9ca739d9a15c004606401e080171e6b3bbf1154f3abf19a2ef562421233acf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2452512642&rft_id=info:pmid/&rft_wanfj_id=ctyxyj_e202001008&rfr_iscdi=true