Activities of a Novel Phenanthrene Imine to Kill Tumor Cells

A novel phenanthrene imine was synthesized from 9,10-phenanthrenequinone, 1,4-diazabicyclo octane （Dabco）, 2,6-dimethylaniline, 2,6-diisopropylaniline and TIC14 via standard Schlenk and vacuum-line or glovebox techniques. 3-（4,5-Dimethylthiazolyl-2）-2,5-diphenyltetrazolium bromide（MTT） assay and flo...

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Bibliographic Details
Published in:Chemical research in Chinese universities 2013-08, Vol.29 (4), p.721-723
Main Authors: Wang, Xu-dong, Jin, Li-min, Sun, Zhi, Li, Dong-ni, Liu, Tie-mei
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
DABCO
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
二异丙基苯胺
二甲基苯胺
亚胺
化合物
流式细胞术
肿瘤细胞
菲醌
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Summary:A novel phenanthrene imine was synthesized from 9,10-phenanthrenequinone, 1,4-diazabicyclo octane （Dabco）, 2,6-dimethylaniline, 2,6-diisopropylaniline and TIC14 via standard Schlenk and vacuum-line or glovebox techniques. 3-（4,5-Dimethylthiazolyl-2）-2,5-diphenyltetrazolium bromide（MTT） assay and flow cytometry（FCM） were used to detect the activities of the compound to kill tumor cells and the mechanisms of action were investigated in the study. The results show that the compound is active in killing tumor cells. Mechanistic investigations found that the compound could induce apoptosis of tumor cells.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-013-3250-0