Volume-related Efficiency of Gadolinium Polyoxometalates as MRI Contrast Agents

Two gadolinium polyoxometalates, KCs4[Gd（a-SiW11O39）].25HzO（POM-1） and K13[Gd（f12-SiWllO39）a]·27H2O（POM-2）, have been evaluated as the candidates of potential magnetic resonance imaging Tl（longitudinal relaxation） contrast agents. Longitudinal relaxivities of POM-2 are much higher than those of POM-...

Full description

Saved in:
Bibliographic Details
Published in:Chemical research in Chinese universities 2013-12, Vol.29 (6), p.1055-1058
Main Authors: Kong, Da-liang, Wei, Bo, Zhou, Sheng-yan, Yang, Hai-shan, Jiang, Yang
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
MRI造影剂
Organic Chemistry
Physical Chemistry
人血清白蛋白
体积
多金属
氧
蛋白相互作用
钆
静电相互作用
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two gadolinium polyoxometalates, KCs4[Gd（a-SiW11O39）].25HzO（POM-1） and K13[Gd（f12-SiWllO39）a]·27H2O（POM-2）, have been evaluated as the candidates of potential magnetic resonance imaging Tl（longitudinal relaxation） contrast agents. Longitudinal relaxivities of POM-2 are much higher than those of POM-1 in pure water and protein solution, respectively. However, compared with POM-1, POM-2 interacts with protein more strongly through electrostatic interaction, which is comfirmed by the fluoresence quenching of human serum albumin（HSA） in solu- tions with different polyoxometalate concentrations. Meanwhile, POM-1 presentes much lower cytotoxicity in the cell viability tests.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-013-3061-3