Preparation and Investigation of Arsenic Trioxide-loaded Polylactic Acid/Magnetic Hybrid Nanoparticles

In order to improve the therapeutic index and reduce the side effects of As2O3 so as to expand its clinical utility to solid tumors,As2O3-loaded polylactic acid（PLA）/magnetic nanoparticles（PAMNs） were prepared and the preparation conditions were optimized by the improved double emulsion solvent-evap...

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Bibliographic Details
Published in:Chemical research in Chinese universities 2014-04, Vol.30 (2), p.326-332
Main Authors: Song, Xiaoli, You, Juan, Wang, Juan, Zhu, Aiping, Ji, Lijun, Guo, Rong
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
SMMC-7721细胞
三氧化二砷
制备条件
原子荧光光谱仪
磁性纳米粒子
磁性纳米颗粒
纳米杂化
聚乳酸
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Summary:In order to improve the therapeutic index and reduce the side effects of As2O3 so as to expand its clinical utility to solid tumors,As2O3-loaded polylactic acid（PLA）/magnetic nanoparticles（PAMNs） were prepared and the preparation conditions were optimized by the improved double emulsion solvent-evaporation method to obtain as a drug delivery system with a high As2O3 encapsulation efficiency and homogeneous nanosized particles.Successful loading of magnetic nanoparticles into the nanoparticles was confirmed by Fourier transform infrared（FTIR） spectroscopy.The drug loading,encapsulation efficiency and releasing properties of As2O3 in PAMNs were investigated by atomic fluorescence spectrometer analysis.Subsequently,the in vitro antitumor efficacy of free As2O3 and As2O3-PAMNs against SMMC-7721 cell line was investigated.Finally,confocal fluorescence microscopy was conducted to reveal the celluar uptake of As2O3-loaded PAMNs by SMMC-7721 cell line.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-014-3306-9