One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-α]pyridines Under Solvent-free Conditions

A direct and efficient approach to synthesize imidazo[1,2-α]pyridines through three-component one-pot reaction of 2-aminopyridine,aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed.This method provides a rapid access to substituted imidazo[1,2...

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Bibliographic Details
Published in:Chemical research in Chinese universities 2014-08, Vol.30 (4), p.632-638
Main Authors: Zong, Chenglong, Zeng, Runsheng, Zou, Jianping
Format: Article
Language:English
Subjects:
2-氨基吡啶
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
一锅反应
催化合成
取代咪唑
快速访问
无溶剂条件
铜纳米粒子
铜纳米颗粒
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Summary:A direct and efficient approach to synthesize imidazo[1,2-α]pyridines through three-component one-pot reaction of 2-aminopyridine,aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed.This method provides a rapid access to substituted imidazo[1,2-α]pyridines with good yields（up to 85％）.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-014-3520-5